What is Furosemide: How to use, side Effects, Dosage

What is Furosemide: How to use, side Effects, Dosage

What is Furosemide

Furosemide is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. It is a loop diuretic (water pill) that prevents your body from absorbing too much salt. This lets the salt to instead be passed in your urine. Furosemide is also used to cure high blood pressure (hypertension).

The CAS Registry Number is 54-31-9.LASIX is a diuretic which is an anthranilic acid derivative .LASIX tablets for oral administration contain furosemide as the active ingredient and the following inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF. Chemically, it is 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. It is practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids.

LASIX is available as white tablets for oral administration in dosage strengths of 20, 40 and 80 mg. Furosemide is a white to off-white odorless crystalline powder.

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How to use Furosemide

Take the liquid medicine with a syringe dose, or with a special spoon for a dose or medicine cup. If you do not have a dose measuring device, ask your pharmacist for one.

Furosemide often urine you and can easily be removed from the water. Follow your doctor's instructions for using potassium supplements or taking salt and potassium in your diet.

Dosage of Furosemide

3Dosage is based on your medical condition, age, and response to treatment. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose or take it more often than directed. For children, the dose is also based on their weight.

Symptoms of Furosemide

Symptoms of over dose may include thirst or warmth, severe sweating, warm and dry skin, severe weakness.

Side effects of Furosemide

Call your doctor at once if you have:

Ringing in your ears, hearing loss;

Easy bruising, unusual bleeding;

Sudden weakness or ill feeling, fever, chills

Painful or difficult urination;

Numbness, tingling, or burning pain;

A light-headed feeling, like you might pass out;

High blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;

Signs of liver or pancreas problems - loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, dark urine, jaundice (yellowing of the skin or eyes);

Kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

signs of an electrolyte imbalance - dry mouth, increased thirst, mood changes, weakness, drowsiness, lack of energy, muscle pain, fast heartbeats, feeling restless, nausea, vomiting.

Common furosemide side effects may include:

Diarrhea, constipation;

Numbness or tingling;

Headache, dizziness; or

Blurred vision.

This is not a complete list of side effects and others may occur.

Gastrointestinal System Reactions are:

Hepatic encephalopathy in patients with hepatocellular insufficiency

 Pancreatitis

 Jaundice (intrahepatic cholestatic jaundice)

Increased liver enzymes

Anorexia

Oral and gastric irritation

Cramping

Diarrhea

Constipation

Nausea

Vomiting

Systemic Hypersensitivity Reactions

Severe anaphylactic or anaphylactic reactions (e.g. with shock)

Systemic vasculitis

Interstitial nephritis

Necrotizing anxieties

Central Nervous System Reactions

Tinnitus and hearing loss

Paresthesias

Vertigo

Dizziness

Headache

Blurred vision

Xanthopsia

Hematologic Reactions

Aplastic anemia

Thrombocytopenia

Agranulocytosis

Hemolytic anemia

Leukopenia

Anemia

Eosinophilia

Dermatologic-Hypersensitivity Reactions

Toxic epidermal necrolysis

Stevens - Johnson syndrome

Erythema multiform

Drug rash with eosinophilia and systemic symptoms

Acute generalized exanthemata's pustulosis

Exfoliative dermatitis

Bullous pemphigoid

Purpura

Photosensitivity

Rash

Pruritis

Urticaria

Cardiovascular Reaction

Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics.

Increase in cholesterol and triglyceride serum levels

Other Reactions

Hyperglycemia

Glycosuria

Hyperuricemia

Muscle spasm

Weakness

Restlessness

Urinary bladder spasm

Thrombophlebitis

Fever

Whenever adverse reactions are moderate or severe, LASIX dosage should be reduced or therapy withdrawn.

Furosemide

Please if you have any questions about Furosemide, you can ask us by commenting below this text, we'll answer you as soon as possible.

Drugs that may interact with Furosemide

Sometimes the use of certain medications is not safe at one time. Some medications can affect your other drugs, which may increase side effects or less effective medications.

If you take Socructure, get your furosemide dose 2 hours or 2 hours after taking sacra lot.

Tell your doctor about all your current medications and start and stop everything, especially:

Chloral hydrate;

Lithium;

Heart medicine or blood pressure; or

Finitehin;

Cancer drugs such as cisplatin;

Other diuretics, especially ethacryntic acid.

LASIX should not be used concurrently with ethacrynic acid due to the possibility of ototoxicity. Patients who receive high doses of salicycule simultaneously with LASIX, as they are in rheumatoid arthritis, may have salicylate toxicity at lower doses than kidney degrading toxins.

Lasers may increase the auto-toxicity of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in situations of life threatening, avoid this combination.

If cisplatin and LASIX are taken at the same time, there is a risk of auto-toxic effects. In addition, when using LASIK at low doses and with positive fluid balance when using obligatory diuresis during cisplatin treatment, side effects of nephrotoxic drugs such as cisplatin are increased.

The lens tends to weaken the ossicular musculoskeletal system of the tobucciurium and may enhance the succinylcholine action.

LASIX together with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers may result in severe hypotension and aggravation of renal function, including renal failure. Cutting or lowering the dose of LASIX, angiotensin converting enzyme inhibitors or receptor influenza may be necessary.

Lithium in general should not be used with diuretics because it reduces lithium blood cholesterol and increases the risk of lithium toxicity.

Potentiation occurs with ganglionic or peripheral adrenocortical blocking drugs.

Lasers may reduce the arterial response to light neoprene. However, norepinephrine can still be used effectively.

Concomitant administration of Sucral tablets and LASIK tablets may reduce the effects of nitrosate and anti-hypertensive LASIX. Patients taking both drugs should be closely monitored to determine if the essential oil needed for diuretics and / or antihypertensive LASIX is obtained. The use of LASIX and Sucrallet should be separated at least two hours.

In separate cases, LASIX intravenous injection within 24 hours after taking chlorate hydrate may lead to intoxication, sweating, lethargy, nausea, increased blood pressure and tachycardia. Therefore, the use of LASIK with chlorate hydrate is not recommended.

Methotrexate and other drugs that are secreted by significant tubes like LASIX may decrease the effect of LASIX. On the contrary, LASIX may reduce renal dysfunction of other drugs that are secreted by the tube. High-dose treatment of both lasers and other drugs may increase the serum levels of these drugs and may increase their toxicity as well as the toxicity of LASIK.

Phenytoin interferes directly with the LASIX kidney function. There is some evidence that phenytoin treatment reduces the absorption of LASIX intestine and thus reduces serum furosemide levels.

Laskax can increase the risk of cephalosporin toxicity, even in cases of short-term renal or partial disorder.

Concomitant use of cyclosporine and LASIX is associated with increased risk of arthritis in the secondary germs due to leukemia and hyperuricemia resulting from the destruction of cyclosporine from renal excretion.

High doses of furosemide (> 80 mg) may cause thyroid hormones to bind to proteins, which can prolong the release of free thyroid hormones and reduce the total thyroid hormones.

A study in six cases showed that a combination of furosemide and acetylsalicylic acid reduced the creatinine levels temporarily in patients with chronic renal failure. There are case reports from patients that increase BUN, serum creatinine, serum potassium levels and weight gain when using furosemide in association with NSAIDs.

Literary reports indicate that the co-ordination of indomethacin may reduce the metabolic and anti-hypertensive effects of LASIX (furosemide) in some patients by inhibiting the prostaglandin synthesis. Endomethacin may also affect plasma renin levels, estradiol deficiency and Renin's evaluation. Patients receiving both endomethacin and laska should be closely monitored to determine if the effect of the diuretic and / or antihypertensive required by LASIX is obtained.

For whom Furosemide might not be safe

You should not use furosemide if you have allergies, or:

If you are not able to urinate.

Tell your doctor if you are to ensure that furosemide is safe for you.

Kidney disease;

Cirrhosis or other liver disease;

Electrolytic imbalance (such as low levels of potassium or magnesium in your blood);

High cholesterol or triglyceride (a type of blood lipids);

Lupus;

Prostate enlargement, bladder obstruction, urinary problems;

Gout

Diabetes; or

Sulfa allergy allergy.

Tell a doctor if you have a magnetic resonance imaging (MRI) or any kind of scan using a radioactive dose injected into your veins. Both color contrast and furosemide can damage your kidneys.

Can you use Furosemide while pregnancy?

During pregnancy, this drug should be used only when clearly needed. Discuss the risks and benefits with your doctor.

For pregnant women: Furosemide is a category C pregnancy drug. That means two things:

Research in animals has shown adverse effects to the fetus when the mother takes the drug.

There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Warnings of Furosemide

In the liver coma and in the case of electrolyte drainage, treatment should not be performed until the basic conditions have been improved. In patients with cirrhosis of the liver and ascites, LASIX treatment should be better started in the hospital. Sudden changes in fluid and electrolyte balance in patients with cirrhosis may cause liver toxicity; therefore, careful observation during the course of the diuresis is necessary. Additional potassium chloride and, if necessary, an aldosterone antagonist help prevent hypokalaemia and metabolic alkalosis.

If increased comfort and oliguria occur during the treatment of advanced liver disease, the lens should be discontinued.

The cases of tinnitus and hearing impairment are reversible or irreversible and reported. Reports generally indicate that LASIX Ototoxicity is indicated for rapid injection, severe renal impairment, higher doses, hypoproteinemia or co-administration with aminoglycoside antibiotics, anthropic acid, or other auto-toxic drugs. If a physician is to use high-dose injectable therapy, intravenous injection is recommended (for adults, the injection rate is greater than 4 ml LASIK per minute).

Furosemide

Please if you have any questions about Furosemide, you can ask us by commenting below this text, we'll answer you as soon as possible.

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