What is Famotidine: How to use, Dosage, Side Effects

What is Famotidine: How to use, Dosage, Side Effects

What is Famotidine

Famotidine is used to treat and prevent gastric and ulcer ulceration. Also, the conditions that cause the stomach to cause too much acid, such as Zollinger-Ellison sulfur. It is a histamine-2 blocker. Famotidine works by reducing gastric acid intake.

Famotidine is also a treatment for gastroesophageal reflux disease (GERD) and other conditions that cause acid in the stomach to empty into morphine and cause stomach upset.

Famotidine may also be used for the purposes out of this medication guide.

Famotidine is a white to yellow autumn crystalline mixture that is freely soluble in glacial acetic acid, slightly soluble in methanol, slightly soluble in water, and practically insoluble in ethanol.

Each oral tablet contains 20 or 40 mg flavutidine and the following inactive substances: hydroxypropylcellulose, hypromellose, iron oxide, magnesium stearate, microcrystalline cellulose, corn starch, talc, titanium dioxide and carnauba wax.

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How to use Famotidine?

Measure liquid drug with the dosing syringe that has been provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Although most ulcers heal within 4 weeks of famotidine treatment, it may take up to 8 weeks of using this medicine before your ulcer heals. For best results, keep using the drug as suggested by your doctor. Talk with your doctor if your symptoms do not improve after 6 weeks of treatment.

Famotidine may be only part of a complete program of treatment that also includes changes in diet or lifestyle habits. Follow your doctor's instructions very closely. Throw away any unused liquid medicine that is older than 30 days.

Dosage of Famotidine

Acute treatment:

It is recommended that adult oral analgesia for a duodenal ulcer is 40 mg once a day at bedtime. Most patients recover within 4 weeks, there is rarely any reason to use PEPCID at full dose for 6 to 8 weeks. The regimen of 20 mg b.i.d. It is also effective.

Maintenance treatment: The recommended oral dose is 20 mg once a day when you are sleeping.

Benign gastric ulcer

Acute treatment: It is recommended that adults oral gastric ulcer gastric ulcer 40 mg once a day while sleeping.

Gastroesophageal reflux disease (GERD)

Recommended dose for the treatment of adult patients with GERD symptoms 20 mg. Up to 6 weeks. An oral dose is recommended for the treatment of adult patients with udvagagitis, including erosion and ulcers and symptoms associated with GERD of 20 or 40 mg / dL. For 12 weeks (See CLINICAL PHARMACOLOGY in adults, a clinical study).

Dosage for 1year old children with gastroesophageal reflux disease (GERD)

Take caution children of less than 1 year olds.

Studies described in precautionary statements show children in children <1 years of age, starting doses in children under 1 year of age: GERD -0.5 mg / kg / dose of phosphatidine for the treatment of GERD for up to 8 weeks once a day in patients less than 3 months and 0.5 mg / kg / dose twice daily in patients 3 months to 1 year. Patients should also receive conservative measures (such as thickened foods). The use of intravenous femotidine has not been investigated in patients with GERD children less than 1year old.

Daily intake of children aged 1 to 16 years

Caution: Children aged 1-16 years old.

Preventive studies, children aged 1-16 years, recommend initial doses in children aged 1 to 16 years:

Peptic ulcer - 0.5 mg / kg p.m. At bed time or split b.i.d. Up to 40 mg per day.

Stomach reflux disease with or without esophagitis including gastric erosion and ulcers - 1.0 mg / kg / day p.o. Split b.i.d. Up to 40 mg b.i.d.

While uncontrolled studies indicate the effectiveness of famotidine in the treatment of gastroesophageal reflux disease and peptic ulcer, information in pediatric patients is not enough to determine the response rate with dose and duration of treatment. Therefore, the duration of treatment (initially based on the recommendations of the adult) and the dose should be based on the clinical response and / or the determination of PH (stomach or esophagus) and separate endoscopy. Published indirect clinical studies are used in children 1 to 16 years of age with a dose of 1 mg / kg / day for gastric ulcer and 2 mg / kg / day for GERD with or without mesopha, including erosion and ulcer.

Pathological Hypersecretory Conditions (for example, Zollinger-Ellison Syndrome, Endocrine Multiple Adenomas)

The dose of PEPCID is different in patients with Hypersecretory pathological disorders. The initial oral dose is 20 mg for 6 hours for the Hypersecretory pathological condition. In some patients, a higher starting dose may be higher. The dose should be adjusted to individual needs and should be continued until clinically indicated. Doses up to 160 mg for 6 hours have been injected into some adults with severe Zollinger-Ellison syndrome.

Simultaneous consumption of anti-acids

If necessary, the antacids may be taken at the same time.

Adjustment of dosage for patients with severe renal insufficiency

In adults with moderate renal insufficiency (creatinine corneal <50 mL / min) or severe (creatinine <10 mL / min), half-life of PEPCID increases. For patients with severe renal failure, it may take more than 20 hours, about 24 hours for stroke patients. Since CNS side effects have been reported in patients with moderate and severe renal insufficiency, in order to prevent excessive accumulation of drug in patients with moderate or severe renal insufficiency, the PEPCID dose may be reduced by half or possible The medication time interval is long, to 36-48 hours, as shown by the patient's clinical response.

Based on the comparisons of pharmacokinetic parameters for PEPCID in adults and children, dose adjustment in children with moderate to severe renal insufficiency should be considered.

Symptoms of overdose

Its side effects in oral administration are similar to the side effects seen in the clinical experience (see unwanted reactions). Oral doses up to 640 mg / day have been given to adult patients with known undesired side effects of hypertrophy. In the event of excessive transmission, the treatment should be symptomatic and supportive.

The oral LD50 oral dose of famoitidin in mice was greater than 3,000 mg / kg and the acute sweetness in dogs was at least 2,000 mg / kg. Famotidine did not cause sudden side effects in high oral doses in mice, mice, cats, and dogs, but caused severe irregularities and severe depression in rabbits at 200 mg / kg / day. Intravenous LD50 of famotidine for mice and rats was from 2563 mg / kg to 254 mg / kg and the minimum single dose of IVV in dogs was about 300 mg / kg. Signs of acute poisoning in IV. Treated dogs, ulcer, numbness, ingestion of mucous membranes or redness of the mouth and ears, hypotension, tachycardia, and falls.

Unsafe materials should be removed from the gastrointestinal tract, the patient should be monitored and supportive care should be taken.


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Side effects of Famotidine

If any of these signs of an allergic reaction to famotidine ,get medical help quickly: hive; severe breathing of the face, lips, tongue or throat.

Stop using famotidine and contact your doctor if you have:

Rapid heartbeat or stroke with severe dizziness; or

Unexplained muscle pain, tenderness or weakness, especially if you have fever, unusual fatigue and dark urine.

The following other adverse reactions have been reported infrequently in clinical trials or since the drug was marketed. The relationship to therapy with PEPCID has been unclear in many cases. Within each category the adverse reactions are listed in order of decreasing severity :( copied by respecting to the source websites priority)

Body as a Whole: fever, asthenia, fatigue

Cardiovascular: arrhythmia, AV block, palpitation. Prolonged QT interval, in patients with impaired renal function, has been reported very rarely.

Gastrointestinal: cholestatic jaundice, hepatitis, liver enzyme abnormalities, vomiting, nausea, abdominal discomfort, anorexia, dry mouth

Hematologic: rare cases of agranulocytosis, pancytopenia, leukopenia, thrombocytopenia

Hypersensitivity: anaphylaxis, angioedema, orbital or facial edema, urticaria, rash, conjunctival injection

Musculoskeletal: rhabdomyolysis, musculoskeletal pain including muscle cramps, arthralgia

Nervous System/Psychiatric: grand mal seizure; psychic disturbances, which were reversible in cases for which follow-up was obtained, including hallucinations, confusion, agitation, depression, anxiety, decreased libido; paresthesia; insomnia; somnolence. Convulsions, in patients with impaired renal function, have been reported very rarely.

Respiratory: bronchospasm, interstitial pneumonia

Skin: toxic epidermal necrolysis/Stevens-Johnson syndrome (very rare), alopecia, acne, pruritus, dry skin, flushing

Special Senses: tinnitus, taste disorder

Other: rare cases of impotence and rare cases of gynecomastia have been reported; however, in controlled clinical trials, the incidences were not greater than those seen with placebo.

The adverse reactions reported for PEPCID Tablets may also occur with PEPCID for Oral Suspension.

Pediatric Patients

In a clinical study in 35 pediatric patients < 1 year of age with GERD symptoms [e.g., vomiting (spitting up), irritability (fussing)], agitation was observed in 5 patients on famotidine that resolved when the medication was discontinued.

Drugs that may interact with Famotidine

Tell each of your health care proiders about all medicines you use now and any medicine you start or stop using. Other drugs may interact with famotidine, including prescription and over-the-counter medicines, vitamins, and herbal products.

No drug interactions have been identified. Studies on famoididine in humans have demonstrated in animal and laboratory models that there is no significant interference in the metabolites metabolised by liver microsomal enzymes, such as the cytochrome P450 system. The compounds tested in humans include warfarin, theophylline, phenytoin, diazepam, aminopyrin and antipyrene. Indocyanine green has been tested as an indicator of hepatic drug extraction, and no significant effects have been achieved.

For whom Famotidine might not be safe

Heartburn is often mistaken by the first signs of a heart attack. If you have pain or chest tightness, and your pain turns on your jaw and shoulders, nausea, sweating and malignancy, seek emergencical cares immediately.

You should not use this medication if you are allergic to famotidine or to similar drugs such as ranitidine (zantachas), caymatidine (Tagamet), or nicididine (Axid).

Consult your doctor about the below illneses in order to know it would be safe for you to use this drug, although you have following disease:

Liver disease;

Kidney disease;

Stomach cancer; or

Personal or family history of long QT syndrome.

3-Do not use this medication in children younger than 12 unless suggested by the doctor.

Older adults may be more sensitive to the side effects of this drug, especially confusion.

Can you use Famotidine while pregnancy?

Reproductive studies have been performed in rats and rabbits at oral doses of up to 2000 and 500 mg/kg/day, respectively, and in both species at I.V. doses of up to 200 mg/kg/day, and have revealed no significant evidence of impaired fertility or harm to the fetus due to PEPCID. While no direct fetotoxic effects have been observed, sporadic abortions occurring only in mothers displaying marked decreased food intake were seen in some rabbits at oral doses of 200 mg/kg/day (250 times the usual human dose) or higher. There are, however, no adequate or well-controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Warnings of Famotidine


Some signs may actually be symptoms of a more serious illness. If you have: dizziness with dizziness / sweating / dizziness, chest pain / jaw / arm / shoulder (especially with shortness of breath, abnormal sweating), unexplained weight loss.

If you have any of the following health problems, consult your doctor or pharmacist before using this medicine: kidney problems, liver problems, stomach problems (eg, tumors).

In addition, get medical help immediately if you have any of these symptoms before you treat yourself with this medicine: pain / pain in eating, vomiting of bleeding, vomiting, which appears to be Like the place of coffee, blood / black stool, headache for more than 3 months, frequent chest pain, frequent fatigue (especially heartburn), nausea / vomiting, stomach ache.

This chewable form contains aspartame. If you have phenylketonuria (PKU) or any other condition that requires an aspartame (or phenylalanine) use restriction, talk to your doctor or pharmacist for the safe use of this drug.


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