What is Amitriptyline: Side Effects, Dosage, How to Use

What is Amitriptyline: Side Effects, Dosage, How to Use

What is Amitriptyline

Amitriptyline is a tricyclic antidepressant and approved for treatment of depression. It is also useful in treatment of chronic neuropathic pain. Amitriptyline affects chemicals in the brain that may be unbalanced in people with depression.

Amitriptyline can be also used to treat post-herpetic neuralgia, attention deficit hyperactivity disorder (ADHD), and certain eating disorders.

It may also be used to prevent symptoms of migraine. Amitriptyline elevates mood by raising the level of neurotransmitters in brain tissue.

Like all TCAs, amitriptyline increases levels of norepinephrine and serotonin, two neurotransmitters, and blocks the action of acetylcholine, another neurotransmitter.

Amitriptyline sometimes known by its former brand name, Elavil, but its manufacturer, AstraZeneca, stopped making it.

Please if you have any questions about Amitriptyline, you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Amitriptyline

Amitriptyline can be used with or without food. Amitriptyline is taken as tablets or syrup every day. It has a sedative effect and may make you drowsy, so you should take it an hour or two before bedtime (but no later than 8 pm).

If you wish to stop taking Amitriptyline you'll probably be advised to reduce the dose gradually over a few weeks to avoid sleep disturbance.

The effect on sleep is usually immediate, and your pain and mood are likely to improve over 2–6 weeks, this means If amitriptyline works for you, because it can sometimes take a while to find the right dose, it's often helpful to keep taking amitriptyline.

Dosage of Amitriptyline

Amitriptyline's recommended adult dose is 100-300 mg daily in divided doses or at bedtime. The initial dose is 50-100 mg at bedtime that may be increased by 25 or 50 mg at bedtime as needed. The lowest effective dose should be used.

Amitriptyline used to be used in high dosage (around 15mg daily) to treat depression, and it is still called an "anti-depression" on the packet insert, even though no one Use it for than anymore.

Tablets of Amitriptyline are available in this dosages: 10, 25, 50, 75, 100, and 150 mg.

Drugs that may interact with Amitriptyline

Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenalgine, rasagiline, selegiline, tranylcypromine, and others.

Epinephrine should not be used with amitriptyline, since together they can cause severe high blood pressure.

Cimetidine (Tagamet) can increase blood levels of amitriptyline and its side effects by preventing the elimination of amitriptyline.

Alcohol blocks the antidepressant action of amitriptyline but increases its sedative effect. It's recommended you should avoid alcohol while you're on amitriptyline because it increases the effects of alcohol and may make you drowsier.

Painkillers such as codeine or tramadol alongside amitriptyline could make you drowsier.

Combination of an SNRI or SSRI antidepressant and amitriptyline, may need more careful monitoring, especially on treatment for blood pressure or heart problems.

And also this drugs may cause problem if interact with Amitriptyline: citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).


Please if you have any questions about Amitriptyline, you can ask us by commenting below this text, we'll answer you as soon as possible.

Amitriptyline may not be safe for those who have:

A heart attack recently, bipolar disorder (manic-depression) or schizophrenia; a history of mental illness or psychosis; liver disease; heart disease; a history of heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Breastfeeding while you're on amitriptyline is unlikely to be harmful. Discuss this with your doctor if you do wish to breastfeed. Very little of the drug has been found in the breast milk of mothers taking high doses of amitriptyline.

Side Effects of Amitriptyline

Some side effects of amitriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Other side effects may include:

Abdominal or stomach pain


black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in consciousness

changes in patterns and rhythms of speech

chest pain or discomfort


cold sweats



confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in ears


cool, pale skin

cough or hoarseness

dark urine

decrease in frequency of urination

decrease in urine volume

decreased urine output

difficulty in breathing

difficulty in passing urine (dribbling)

difficulty in speaking

disturbance of accommodation

disturbed concentration

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

double vision


dry mouth



false beliefs that cannot be changed by facts

fast, slow, or irregular heartbeat

fear or nervousness

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness


hearing loss

high fever

high or low blood pressure


inability to move arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased ocular pressure

increased sweating

increased thirst

increased urination


lack of coordination


light-colored stools

lip smacking or puckering

loss of appetite

loss of balance control

loss of bladder control

loss of consciousness

lower back or side pain

mental depression or anxiety

muscle spasm or jerking of all extremities

muscle tightness

muscle trembling, jerking, or stiffness

muscle twitching

nausea and vomiting

nightmares or unusually vivid dreams

overactive reflexes

painful or difficult urination

passing urine more often

pinpoint red spots on skin

poor coordination

pounding in the ears

puffing of cheeks

rapid or worm-like movements of tongue

rapid weight gain


seeing, hearing, or feeling things that are not there


severe muscle stiffness

shakiness and unsteady walk


shortness of breath

shuffling walk


slow speech

slurred speech

sore throat

sores, ulcers, or white spots on lips or in mouth

stiffness of limbs


sudden loss of consciousness


swelling of face, ankles, or hands

swelling or puffiness of face

swollen glands

talking or acting with excitement you cannot control

trouble in speaking

trouble sleeping

troubled breathing

twisting movements of body pain or discomfort in arms, jaw, back, or neck

unable to sleep

uncontrolled chewing movements

uncontrolled movements, especially of arms, face, neck, back, and legs

unexplained weight loss

unpleasant breath odor

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual tiredness or weakness

unusually pale skin

upper right abdominal pain

vomiting of blood

weakness in arms, hands, legs, or feet

weight gain or loss

yellow eyes and skin

Bigger, dilated, or enlarged pupils (black part of eye)

black tongue


breast enlargement in females


decreased interest in sexual intercourse


hair loss, thinning of hair

hives or welts

inability to have or keep an erection

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

increased sensitivity of eyes to light

loss in sexual ability, desire, drive, or performance

loss of sense of taste

redness or other discoloration of skin

severe sunburn

skin rash

swelling of testicles

swelling of the breasts or breast soreness in males

swelling of the parotid glands

swelling or inflammation of the mouth

Unexpected or excess milk flow from breasts.


Over dose of Amitriptyline:

 Clumsiness, drowsiness, low body temperature, muscle aches, muscle weakness, sleepiness, tiredness, and weak or feeble pulse.

Please if you have any questions about Amitriptyline, you can ask us by commenting below this text, we'll answer you as soon as possible.

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