ZIAC (Bisporol Fumarate and Hydrochlorothiazide): Full Information

ZIAC (Bisporol Fumarate and Hydrochlorothiazide): Full Information

What is Ziac?

This drug combination is used to treat high blood pressure (high blood pressure). Reducing high blood pressure helps prevent stroke, heart attacks and kidneys.

ZIAC (Bisporol Fumarate and Hydrochlorothiazide) are indicated for treating high blood pressure. The two antihypertensive drugs combine in single dose doses: one of the contraceptives (selective heart) of adrenergic basperolum fumarate and a diuretic benzoate diazine (hydrochlorothiazide).

Bioprolol fumarate is chemically called (±) -L- [4- [[2- (1-methyylethoxy) ethoxy] methyl] phenoxy] -3 - [(1-methyylethyl) amino] -2-propanol (E) - 2-Butenedioate (2: 1) (Salt). It has an asymmetric carbon core in its structure and is provided as a rachitic mixture. The S (-) enantiomer is responsible for most beta-blocking activities. Its empirical formula (C18H31NO4) 2 is C4H4O4 and its molecular weight is 766.97.

This product contains two medicines. Bioprolol is a beta blocker that acts by blocking the effects of some natural chemicals (such as epinephrine) on the heart and blood vessels. This lowers your heart rate, reduces blood pressure and reduces heart pressure. Hydrochlorothiazide is a water pill (diuretic) that works by increasing the amount of urine you make. This will help your body get rid of excess salt and water, which probably helps blood vessels to flow more easily. These two drugs are taken together when a medication does not control your blood pressure. With these two drugs, you can reduce the amount of each drug you need, thus reducing the likelihood of side effects.

Ziac is a combination of hydrochlorothiazide and bisoprolol. Hydrochlorothiazide is a diuretic thiazide (a water pill) that helps your body absorb too much salt, which can keep fluids up.

Bioprolol is a beta-blocker. Beta blockers affects the heart and circulation (blood flow through the arteries and veins).

Ziac Uses

Ziac is used to treat high blood pressure.

Ziac may also not be used for the purposes of this medication guide.

Please if you have any questions about ZIAC (Bisporol Fumarate and Hydrochlorothiazide), you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Ziac?

Take this medicine orally or without food, usually once a day as your doctor. Your blood pressure may be very low when taking Ziac. If you have vomiting or diarrhea, consult your doctor if you are more than usual. Long-term illness can lead to serious electrolyte imbalances, and make you use Ziac.

Your blood pressure should often be checked. If you have vomited or lost, you may test both blood and urine.

If you have diabetes, check your blood sugar carefully. Consumption of bisoprolol may be more difficult than when you have low blood sugar. Your insulin or diabetes drug requirements may change while you are taking Ziac. Change the dose or schedule without your doctor's advice.

Dosage of Ziac

If you also take cholestyamine or cholestyol, take bisoprolol / hydrochlorothiazide at least 4 hours or at least 4 to 6 hours after taking any of these medicines.

Use this medication regularly to get the most benefit from this drug. To help you remember, put it at a time every day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. It may take up to 3 weeks before you get the full benefits of this medication.

Adult consumption for high blood pressure:

Initial dose: Bioprolol 2.5 mg hydrochlorothiazide 6.25 mg once daily.

Maximum dose: Bioprolol 20 mg hydrochlorothiazide 12.5 mg once daily.

Symptoms of over dose 

Symptoms of administration may include confusion, leg cramps, anesthesia and tingling, heart rate, or sudden fatigue. If excessive ZIAC (Bisoprolol Fumarate and Hydrochlorothiazide) is suspected, treatment with ZIAC should be discontinued and the patient should be more careful. Symptomatic and supportive treatment; there is no particular antidote. Limited data suggest that fumarate bipolar cannot be dialysable. Similarly, there is no indication that dialyzable hydrochlorothiazide is. Prophylactic measures include: induction of ulcer and / or gastric larvae, activation of activated charcoal, respiratory support, fluid and electrolyte imbalance correction and seizure therapy. Based on the predicted pharmacological actions and recommendations for other beta-blockers and hydrochlorothiazide, when clinically necessary, it should be considered:

Side effects of Ziac

Hydrochlorothiazide in this product may cause excessive amounts of water and salt (water loss). Tell your doctor immediately if you have severe, severe symptoms of unexpected, but serious symptoms: very dry mouth, severe thirst, muscular cramps / weakness, rapid heartbeat, severe dizziness, fainting, seizures.

In the case that:

Chest pain;

Fast, slow or rough heart rate;

A feeling of dizziness, like you, may disappear;

Vague sight, tunnel vision, eye pain or halo viewing around lights;

Shortness of breath (even with mild exertion), swelling, rapid weight gain;

Low potassium - leg cramps, constipation, irregular heartbeats, dyspnea, severe thirst, increased urine, numbness or tingling, muscle weakness and chills inside you.

Hepatobiliary disorders - Nausea, upper stomach pain, itching, feeling tired, loss of appetite, dark urine, rash, yellow fever (yellowish skin or eyes);

Low blood glucose - headache, hunger, weakness, sweating, confusion, irritability, dizziness, heart rate, or strangulation; or

Severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, then a red or purple skin rash that spreads especially in the face or body and causes flaking and the skin. Vectorized.

Common side effects of ziac may include:

Dizziness, feeling of rotation;

Feeling weak or fatigued

Diarrhea, nausea, stomach upset


Cough, runny nose; or

Sleep problems (insomnia).

This list is not the full list of side effects and others may occur.


Please if you have any questions about ZIAC (Bisporol Fumarate and Hydrochlorothiazide), you can ask us by commenting below this text, we'll answer you as soon as possible.

Drugs that may interact with Ziac

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alpha blockers (e.g., prazosin, terazosin), diazoxide, digoxin, drugs that affect heart rhythm (e.g., disopyramide), fenoldopam, epinephrine, fingolimod, lithium, other drugs for high blood pressure (e.g., clonidine), probenecid, rifamycins (e.g., rifampin), St John's wort.

Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Ziac, especially:

colestipol or cholestyramine;


insulin or oral diabetes medicine;

sedatives or narcotic medicine;

heart or blood pressure medicine - clonidine, digoxin, diltiazem, disopyramide, reserpine, verapamil, and others;

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or

steroid medicine - prednisone and others.

This list is not complete.

For whom Ziac might not be safe

Tell your doctor or pharmacist if you are allergic to bisoprolol or hydrochlorothiazide, or to other beta-blockers (for example, metoprolol, atenolol); or to other thiazide diuretics (for example, chloroticase); Or if you have an allergy. This product may contain inactive material that can cause allergic reactions and other problems. Talk to your pharmacist for more information.

You should not use Ziac if you are allergic to hydrochlorothiazide or bisoprolol, or if you have:

Severe or uncontrolled heart failure

A slow heartbeat that has caused you to choke

A serious heart disease called "sick sinus disease" or "AV block" (2 or 3 degrees); or

If you are not able to urinate

Tell your doctor if you want to ensure Ziac is safe for you.

Congestive Heart Failure;

Asthma or other respiratory disorders


Thyroid disorder;


Peripheral vascular diseases such as Rhytvian syndrome;

kidney disease;

Liver disease (or cirrhosis);


Gout or

Allergy to sulfa or penicillin drugs.

During pregnancy, this medication should only be used when needed. It may be harmed to a baby. Talk with them about the dangers and benefits of the doctor.

This medicine is transmitted to breast milk and can have adverse effects on breast milk. Consult your doctor before breast-feeding.

Ziac is not to be used for people under 18 years of age.

Warnings of Ziac

This medicine may cause dizziness or drowsiness. Alcohol or marijuana can cause your dizziness or sleepiness. Do not drive, use machines, or do anything that you need to be alert to as long as you can safely do it. Limit alcohol drinks. Talk to your doctor if you use marijuana.

Eat lots of fluids when taking this medicine to prevent dizziness. Sweating, diarrhea, or vomiting may cause dizziness. Avoid extreme sports and hot weather. Report long-term diarrhea or vomiting to your doctor.

Other symptoms of low blood sugar, such as dizziness / sweating, do not affect this medication. This product can also make your blood glucose control harder. Check your blood glucose regularly and share your results with your doctor. Tell your doctor if there are signs of high blood sugar such as thirst / urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medicine may lower your blood potassium levels. Ask your doctor about adding potassium to your diet. Potassium supplements may be prescribed by your doctor.


Please if you have any questions about ZIAC (Bisporol Fumarate and Hydrochlorothiazide), you can ask us by commenting below this text, we'll answer you as soon as possible.

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