Spironolactone: How to use, Side Effects, Dosage

Spironolactone: How to use, Side Effects, Dosage

What is Spironolactone?

Spironolactone is a poor potassium diuretic (water pill) that prevents your body from over-absorbing the salt and loses its potassium level. Spironolactone is used to treat heart failure, high blood pressure (hypertension) or hypokalemia.

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How to use spironolactone?

Take the medicine in the mouth, according to the doctor's instructions. If a stomach upset occurs, pour it with food or milk. It is advisable to take your dose before 6 am (12th), so it's not possible to stop sleeping throughout the night for urination. Ask your doctor or pharmacist if you have questions.

If you use the liquid form of this medicine, take the bottle before each dose. Measure the exact dose using a special measuring device / spoon. Do not use a spoon because you may not have a proper dose. You can take the liquid form of this medicine with or without food, but it is important to choose one way and use it with any dose.

Drug use is based on the medical condition and response to treatment. In children, the dose is also based on body weight.

Spironolactone Uses

Use these medications regularly to get the most out of it. Remember to use it at the same time (s) every day. It is important to continue taking spironolactone even if you feel well. Most people with high blood pressure do not feel sick.

Take this medicine exactly. Do not increase your dose, prescribe it more than a prescription, or use this medicine without first consulting your physician. When your medicine suddenly stops, your condition may get worse.

If your condition worsens (for example, if you notice an increase in your blood pressure), tell your doctor.

Dosege of Spironolactone

Aldactone may be taken with or without food. The dosage range is 25-400 mg daily in single or divided doses.

The initial dose for treating edema in adults is 100 mg daily as a single dose or divided doses. The dose may be adjusted after 5 days based on response. The recommended dose range is 25 to 200 mg daily. The initial dose should be continued for at least 5 days before increasing the dose. If there is no adequate response after 5 days, a second diuretic may be added.

The dose for treating high blood pressure(hypertension) is 50 to 100 mg daily in single or divided doses.

The dose for treating hypokalemia is 25 to 100 mg daily.

Overdose Spironolactone

The LD50 oral dose of ALDACTONE in mice, mice and rabbits is greater than 1000 mg / kg.

Acute administration of ALDACTONE may occur with drowsiness, confusion, macular degeneration, erythematosus, nausea, vomiting, dizziness, or diarrhea. Rarely, hyponatremia, hyperkalemia, or comatose liver may occur in patients with severe liver disease, but this is unlikely due to excessive acute transmissions. Hyperkalaemia may occur, especially in patients with renal dysfunction.


It does not cause vomiting or gastric emptying by a special antidote. Treatment for hydration, electrolyte balance, and supportive vital function.

Patients with renal impairment may develop spironolactone hypokalemia. In such cases, ALDACTONE should be discontinued immediately. With severe hypercalemia, the clinical status of the protocols is used. This may include intravenous injection of calcium chloride solution, sodium bicarbonate solution and / or oral or glucose injection with fast acting insulin preparation. These are temporary measures that, if necessary, will be repeated. Cadmium conversion resins such as sodium polystyrene sulfonate may be orally or rectally. Continuous hypokalemia may require dialysis.

Symptoms of overdose

Irregular heartbeat


numbness or tingling in the hands, feet, or lips

rash with flat lesions or small raised lesions on the skin

reddened skin

weakness or heaviness of the legs

Spironolactone while Pregnancy

There are no adequate studies in pregnant women. Aldactone may be harmful if used for treating gestational hypertension (high blood pressure during pregnancy).


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Side effects of Spironolactone

Spironolactone with its effects may cause some unwanted effects. Although not all of these side effects may occur, but if they do occur, they may need medical attention.

Talk to your doctor immediately if you experience any side effects while taking sporunolactone.

  • The incidence is unknown
  • Chewing gum
  • Bloody or black, fecal excretion
  • Bloody urine
  • Blurred vision
  • Chest pain
  • Chest pain
  • Colored colored stool
  • Clear discharge or blood from the nipple
  • Cloudy urine
  • Confusion
  • Constipation
  • cough
  • Dark urine
  • Reduce urine output or reduce your ability to concentrate urine
  • Diarrhea
  • Problem with swallowing
  • Bleeding the skin
  • Dizziness
  • Dizziness, weakness or dizziness Suddenly, when suddenly a lie or sitting position
  • Drowsiness
  • Fast or irregular heartbeat
  • Fever or no chill
  • Feeling tired or weak
  • Headache
  • Heartburn
  • Hives, itching, or itching of the skin
  • Violence
  • Increase thirst
  • Indigestion
  • Reverse Nipple
  • Loss of appetite
  • Loss of vigilance
  • Back pain or pain
  • Mass in the breast or under the arm
  • Muscle aches or muscle cramps
  • Muscle spasm or shaking
  • nausea
  • Urine is painful and difficult
  • Scaling or scaling nipples
  • Identify red spots on the skin
  • Bloated or swollen eyelids around the eyes, face, lips or tongue
  • Redness or swelling of the breasts
  • Seizure
  • Severe stomach pain
  • Fragility and unstable walking
  • Pain on the skin of the breast that can not be treated
  • Sore throat
  • Wounds, wounds, or white spots on the lips or mouths
  • Stomach pain, burning, or sensation
  • Swollen face, fingers, feet, ankles, or lower legs
  • Swollen, painful or tender lymph nodes in the neck, armpit or groin
  • Stomach in the chest
  • Shake
  • Breathing problem
  • Unpleasant odor of breathing
  • Instability, tremor, or other problems with muscle control or coordination
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Vomit
  • Vomiting of blood or substances similar to coffee grounds
  • Weight Gain
  • Yellow eyes or skin

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Drugs that may interact with Spironolactone

Common medications checked in combination with spironolactone

  • Accutane (isotretinoin)
  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • amoxicillin
  • Aspir 81 (aspirin)
  • Aspirin Low Strength (aspirin)
  • Control (phenylpropanolamine)
  • Coreg (carvedilol)
  • Crestor (rosuvastatin)
  • Cymbalta (duloxetine)
  • doxycycline
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • furosemide
  • hydrochlorothiazide
  • ibuprofen
  • Lantus (insulin glargine)
  • Lasix (furosemide)
  • levothyroxine
  • Lipitor (atorvastatin)
  • Lyrica (pregabalin)
  • metformin
  • Metoprolol Succinate ER (metoprolol)
  • Nexium (esomeprazole)
  • phentermine
  • Plavix (clopidogrel)
  • prednisone
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Warnings of Spironolactone

Talk to your doctor or pharmacist before taking spironolactone; if you have allergies, or if you have an allergy. This product may contain inactive material that can cause allergic reactions and other problems. Talk to your pharmacist for more information.

Before using spironolactone, tell your doctor or pharmacist your medical history, in particular: kidney problems, liver problems, inorganic mineral inequalities (such as high potassium, low sodium), decreased adrenal gland function (Edison's disease).

Before your surgery, tell your doctor or dentist all the products you are using (including prescription drugs, over-the-counter prescriptions, and herbal products).

spironolactone may increase your potassium level. Consult your doctor or pharmacist before using potassium supplements or potassium-containing salt substitutes. Limit foods high in potassium, such as bananas, tomatoes, potatoes and low salt juice. For further details, including advice, contact your doctor or pharmacist.

This medicine may cause dizziness or drowsiness. Alcohol or marijuana can cause your dizziness or sleepiness. Do not drive, use machines, or do anything that you need to be alert to as long as you can safely do it. Limit alcohol drinks. Talk to your doctor if you use marijuana.

Elderly adults may be more susceptible to the side effects of spironolactone, especially effects on potassium (see section on side effects).

spironolactone should only be used when clearly needed during pregnancy. Talk with them about the dangers and benefits of the doctor.

This medicine is transmitted to the breast, but it is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.


Please if you have any questions about Spironolactone, you can ask us by commenting below this text, we'll answer you as soon as possible.

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