Xarelto (Rivaroxaban): How to use, Side Effects, Dosage

Xarelto (Rivaroxaban): How to use, Side Effects, Dosage

What is Xarelto?

Xarelto is sometimes used to lower the risk of developing DVT or PE after receiving treatment for blood clotting for at least 6 months.

Xarelto (rivaroxaban) stops certain blood clots in the blood. Rivaroxaban is pure (S) -ananthymor. This powder is odorless, non-hydroscopic, white to yellow. Rivaroxaban is only slightly soluble in organic solvents (such as acetone, polyethylene glycol 400) and is not practically water soluble in media.

Xarelto is used to prevent or treat a blood clot through deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). DVT can occur after certain types of surgery.

Rivaroxaban, an Xa agent (FXa), an active ingredient in XARELTO tablets, with the name of 5-Chloro-N - ({(5S) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -1,3-oxazolidin-5-yl} methyl) -2-thiophenecarboxamide. The molecular formula is rivaroxaban C19H18ClN3O5S and the molecular weight is 435.89. Structural formula:

Xarelto is used in people with atrial fibrillation (heart rhythm disorder) to reduce the risk of stroke due to blood clotting.

Xarelto is also used to decrease the risk of heart attacks and stroke in people with coronary artery disease or peripheral arterial disease.

Please if you have any questions about Xarelto (Rivaroxaban), you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Xarelto?

For some conditions, Xarelto should be taken with food. Whether you take medicine with or without food may also depend on your pill strength. Follow your doctor's dosing instructions very carefully. Take this medicine with your mouth as done by your doctor. If you take this medicine to prevent blood clots after knee replacement surgery or surgery, the dose is usually taken once a day. If you take this medicine to prevent stroke and blood clots that may be due to irregular heartbeats, you will usually take once-daily doses with overnight fast food. If you are taking rivoxab for blood clots, the dose is usually given twice a day for the first 3 weeks and then once a day. To reduce the risk of blood clots, this medicine is usually taken once a day. Carefully follow your doctor's paths. Do not increase your dose, do not take more or stop taking it unless you tell your doctor about it. 10 mg tablets may be taken with or without food. Pills of 15 mg and 20 mg should be taken with food. Ask your doctor or pharmacist if you have questions about how to use rivaroxaban.

If you are not able to swallow all the pill, you can grind the pill and mix it with potatoes. Stir whole mixture. Do not prepare a resource for future use.

Tell your doctor if you have difficulty swallowing your Xarelto pill.

Dosage of Xarelto

The 10 milligrams tablet might be taken with or without food. The 15 milligrams and 20 milligrams tablet should be taken with food. If you have any questions about how to take rivaroxaban, ask your doctor.

Usual Adult Dose of Xarelto for Atrial Fibrillation: The 10 milligrams tablet may be taken with or without food. The 15 milligrams and 20 milligrams tablet should be used with food. If you have any questions about how to take rivaroxaban, ask your doctor.

Usual Adult Dose for Pulmonary Embolism:

Initial dose: 15 mg orally twice a day for first 21 days of therapy

Maintenance dose: 20 mg orally once a day for the remaining duration of treatment.

Usual Adult Dose of Xarelto for Deep Vein Thrombosis:

Initial dose: 15 mg orally twice a day for first 21 days of therapy

Maintenance dose: 20 mg orally once a day for the remaining duration of treatment.

Usual Adult Dose for Deep Vein Thrombosis -- Recurrent Event:

Recommended dose: 10 mg orally once a day

Usual Adult Dose for Pulmonary Embolism -- Recurrent Event:

Recommended dose: 10 mg orally once a day

Use: Reduction in the risk of recurrence of deep vein thrombosis (DVT) and/or pulmonary embolism (PE) in patients at continued risk for recurrent DVT and/or PE after at least 6 months of standard anticoagulant treatment.

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery:

Initial dose: 10 mg orally once a day starting 6 to 10 hours after surgery

Duration of therapy:

Knee replacement surgery: 12 days

Hip replacement surgery: 35 days

Comments: Treatment may be given as long as hemostasis has been established.

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery:

Initial dose: 10 mg orally once a day starting 6 to 10 hours after surgery

Duration of therapy:

Hip replacement surgery: 35 days

Knee replacement surgery: 12 days

Symptoms of over dose 

XARELTO over dose may lead to bleeding. Discontinue discontinuation of XARELTO and start appropriate treatment if bleeding complications occur with over dosage. Systemic exposure to Rivaroxaban in single doses> 50 mg will not increase due to limited absorption. Use of activated charcoal may be considered to reduce absorption if XARELTO is used too much. Due to high protein plasma protein binding, fluorescents are not dialyzed. Minor variations of laboratory anticoagulant parameters are obtained using plasma products. An agent to reverse the activity of Xa antioxidant activity is available.

Xarelto Rivaroxaban

Please if you have any questions about Xarelto (Rivaroxaban), you can ask us by commenting below this text, we'll answer you as soon as possible.

Side effects of Xarelto

If there are signs of a blood clot in the spine, you also seek emergency care: back pain, numbness or muscle weakness in the lower body, or loss of control of the bladder or intestine.

Rivaroxaban can make you bleed more easily. If you have bleeding symptoms such as:

Easy bruising or bleeding (nose bleeding, bleeding gums, severe menstrual bleeding);

Pain, swelling, or drainage of the wound or where a needle is injected into the skin;

Bleeding from the wound or needle injection, any bleeding that will not stop

Headache, dizziness, weakness, feeling like you may be gone;

Urine that turns red, pink or brown; or

Blood or stool is blurry, coughing up blood or vomiting, which seems like a coffee spot.

Bleeding is the most common side-effect of voroxabur.

The usual side effects of Xarelto may include:

Muscular pain

Itchy or

Pain in the arms or legs.

This list is not the full list of side effects and others may occur.

This drug may cause serious bleeding, because this protein causes excessive blood coagulation. Inform your doctor if you have severe bleeding symptoms: abnormal pain / swelling / discomfort, unusual bruising, prolonged bleeding from cutting or gingival, severe / repeated bleeding nose bleeding, unrealistic / prolonged menstrual flow, pink / dark urine, coughing up blood, vomiting, bleeding or appearing, such as coffee, severe headache, dizziness / low back pain, unusual or persistent fatigue / weakness, blood / black / bloodsucking stool, difficulty swallowing.

In case of severe symptoms of bleeding, including: changes in vision, confusion, boredom and weakness on one side of the body, see the doctor in a timely manner.

This allergic reaction is rare. However, if you notice signs of a severe allergic reaction, including itching, itching / swelling (especially throat/ tongue / face), severe dizziness, difficulty breathing, see your doctor in a timely manner.

This is not a complete list of possible side effects. If you notice any other effects not listed above contact your doctor or pharmacist.

Drugs that may interact with Xarelto 

Tell your doctor about all drugs you use, and those you start or stop using during your treatment with Xarelto, especially:

erythromycin;

antifungal medication - Iitraconazole or ketoconazole;

rifampin;

HIV medication - indinavir, lopinavir, ritonavir; or

seizure medication - carbamazepine, phenobarbital, phenytoin.

This list is not complete.

For whom Xarelto might not be safe

Xarelto can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term paralysis, and may be more likely to occur if:

you have a spinal catheter in place;

you have a genetic spinal defect;

you have recently had a spinal tap or epidural anesthesia;

you have a history of spinal surgery or repeated spinal taps;

you are taking a NSAID - Advil, Aleve, Motrin, and others; or

you are using other medicines to treat or prevent blood clots.

Xarelto may cause you to bleed more easily, especially if you have:

a bleeding disorder that is inherited or caused by disease;

hemorrhagic stroke;

uncontrolled high blood pressure;

stomach or intestinal bleeding or ulcer; or

if you use certain medicines such as aspirin, enoxaparin, heparin, warfarin (Coumadin, Jantoven), clopidogrel (Plavix), or certain antidepressants.

Tell your doctor if you have ever had:

an artificial heart valve; or

liver or kidney disease.

Use Xarelto while pregnancy

Taking Xarelto during pregnancy may result in bleeding into the mother or the baby. Tell your doctor if you are pregnant or intend to have a pregnancy.

Warnings of Xarelto

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), stroke, recent major injury/surgery, blood disorders (such as anemia, hemophilia, thrombocytopenia), frequent falls/injuries, certain eye problem (retinopathy), certain hereditary enzyme problems (such as galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption). This medicine can cause bleeding. To reduce the risk of cutting, bruising or damaging, use caution with sharp objects such as shaving and nail cutting. Use a blade when shaving a brush and a soft toothbrush while brushing teeth.

It is important that all your doctors and dentists know that you take rivaroxaban. Before having surgery or any medical/dental procedures, tell your doctor or dentist that you are using this medication. Avoid activities like communication exercises. If you fall or hurt yourself, especially if you tap your head, consult your doctor immediately. Your doctor may check for possible bleeding that may be serious.

At room temperature, keep light and moisture. Do not save in the bathroom. Keep all medications away from children and pets.

Use a chopped pill in 4 hours.

Xarelto Rivaroxaban

Please if you have any questions about Xarelto (Rivaroxaban), you can ask us by commenting below this text, we'll answer you as soon as possible.

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