ZOSYN (Piperacillin, Tazobactam) full information

ZOSYN (Piperacillin, Tazobactam) full information

What is ZOSYN?

Piperacillin/tazobactam or ZOSYN, is a combination medication including the antibiotic piperacillin and the β-lactamase inhibitor tazobactam.The combination works against many Gram-positive and Gram-negative bacteria containing Pseudomonas aeruginosa. It is used to treat pelvic inflammatory disease, intra-abdominal infection, pneumonia, cellulitis, and sepsis.

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How to use ZOSYN?

This medication should be injected in to a vein as directed by your doctor, usually every 6 hours. It should be injected slowly over at least 30 minutes. The dosage depends on your medical situation and response to treatment. For children, the dosage is also based on their age and weight.

To using at home, you should learn all preparation and usage instructions from your care professional. Before using, check this product carefully for particles or discoloration. If you see something like that don’t use it. Learn about storing and discarding medical supplies safely.

For the best influence, use this medicine at evenly spaced times. To remember that, use this medication at the same times every day.

Dosage of ZOSYN

The usual daily dose of ZOSYN for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam)

Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam).

Dosage in patients with renal impairment (≤40 mL/min of CRCL) and dialysis patients should be reduced, based on the degree of actual renal function impairment.

For children with appendicitis and/or peritonitis the recommended ZOSYN dosage is 100 mg piperacillin/12.5 mg tazobactam per kilogram of body weight, every 8 hours in pediatric patients 9 months of age and older. For pediatric patients 2 to 9 months of age, the recommended dosage is 80 mg piperacillin/10 mg tazobactam per kilogram of body weight, every 8 hours. ZOSYN and aminoglycosides should be reconstituted, diluted, and administered separately. Co-administration via Y-site can be done under certain conditions.

Dosage forms and strengths

ZOSYN for Injection: 2.25 g, 3.375 g, and 4.5 g lyophilized powder for reconstitution in single-dose vials and 40.5 g lyophilized powder for reconstitution in pharmacy bulk vials.

ZOSYN Injection: 2.25 g in 50 mL, 3.375 g in 50 mL, and 4.5 g in 100 mL frozen solution in single-dose GALAXY containers.

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Side Effects of ZOSYN

Nausea, constipation, diarrhea, headache, or trouble sleeping may happen. If any of these effects get worse, tell your doctor.

Remember that your doctor has indication this medication because he or she has believed that the profit to you is greater than the risk of side effects. Many people do not have any side effects by using this medicine.

If you have side effects including: easy bruising or bleeding tell your doctor.

This medication hardly cause a severe intestinal condition due to a type of resistant bacteria. This situation happen during treatment or weeks to months after treatment has stopped. If you have diarrhea that doesn’t stop, abdominal or stomach pain, cramping, blood or mucus in your stool tell your doctor.

Don’t use anti-diarrhea or opioidmedications if you have any of these symptoms because these products may make them worse.

Using this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Tell your doctor if you see white patches in your mouth, a change in vaginal discharge, or other new symptoms.

If you have serious side effects including: seizures, signs of kidney problems such as changing in the amount of urine get medical help.

A very serious allergic reaction to this drug is rare. But if you see any symptoms of a serious allergic reaction including: fever that doesn’t go away, new or worsening lymph node swelling, rash, itching/swelling especially of the face, tongue r throat, severe dizziness, trouble breathing getmedical help.

Drug that may interact with ZOSYN

Serious hypersensitivity reactions (anaphylactic/anaphylactoid) reactionshave been reported in patients receiving ZOSYN. Discontinue ZOSYN if a reaction occurs.

ZOSYN administration can significantly reduce tobramycin concentrations in hemodialysis patients. Monitor tobramycin concentrations in these patients.

Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with ZOSYN unless the benefit outweighs the risk.

Co-administration of ZOSYN with vancomycin may increase the incidence of acute kidney injury. Monitor kidney function in patients receiving ZOSYN and vancomycin.

Monitor coagulation parameters in patients receiving ZOSYN and heparin or oral anticoagulants.

ZOSYN may prolong the neuromuscular blockade of vecuronium and other non-depolarizing muscle relaxants. Monitor for adverse reactions related to neuromuscular blockade.

Warnings of ZOSYN

ZOSYN may cause severe cutaneous adverse reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, and acute generalized exanthematous pustulosis. Discontinue ZOSYN for progressive rashes.

Haematological effects (including bleeding, leukopenia and neutropenia) have occurred. Monitor hematologic tests during prolonged therapy.

Nephrotoxicity in critically ill patients has been observed; the use of ZOSYN was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicentre, controlled trial in critically ill patients. Based on this study, alternative treatment options should be considered in the critically ill population. If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with ZOSYN.

Clostridium difficile associated diarrhea: evaluate patients if diarrhea occurs.

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