What is Methacarbamol: Side Effects, Dosage, How to use

What is Methacarbamol: Side Effects, Dosage, How to use

What is Methacarbamol?

Methacarbamol is indicated as a supplement to rest, physiotherapy and other measures to relieve the acute and painful muscular condition. The activity of metacarbamol has not been clearly specified, but may be related to its sedative properties. Methacarbamol does not regenerate human skeletal muscle directly in humans.

Methocarbamol is used to treat muscle spasms/pain. It is usually used along with rest, physical therapy, and other treatment. It works by helping to relax the muscles.

In other word methocarbamol is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Methocarbamol is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Methocarbamol is available under the following different brand names: Robaxin.

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How to use methacarbamol?

Take this medicine with or without food according to your doctor's instructions, usually 3 to 4 times a day.

The dose is based on your medical condition and response to treatment. Do not increase your dose and do not give it over the dose. Your condition will not be faster and the risk of your side effects increases

Tell your doctor if your condition is not improved or it gets worse.

Methacarbamol dosage

Usual Adult Dose for Muscle Spasm


Initial dose: 1500 mg four times a day for the first 48 to 72 hours, up to a maximum dosage of 8 g/day for severe symptoms.

Maintenance dose: 4000 to 4500 mg/day in divided doses.

IV or IM:

1000 mg up to every 8 hours if necessary, not to exceed 3 g/day for more than 3 consecutive days except in the treatment of tetanus. A like course may be repeated after a lapse of 48 hours if the condition persists. Oral therapy should be instituted as soon as possible. For symptoms of moderate severity, oral doses may be adequate after one injection if patient can tolerate oral medications.

Usual Adult Dose for Tetanus

1 to 2 g directly into IV tubing, followed by an additional 1 to 2 g by IV infusion for a total dose of up to 3 g initially. This procedure may be repeated every 6 hours until nasogastric tube can be inserted. Then, crushed tablets suspended in water or saline solution can be given through the nasogastric tube. Total daily oral doses up to 24 g may be required.

Usual Pediatric Dose for Tetanus

Initial dose: 15 mg/kg/dose IV or 500 mg/m2/dose IV, may repeat every 6 hours if needed.

Maximum dose: 1.8 g/m2/day IV for 3 days only

Renal Dose Adjustments

The use of metacarbamol injection form in patients with renal insufficiency is not recommended due to the high concentration of polyethylene glycol in the solution.

Musculoskeletal pain in adults

Initially, take three 500 mg tablets by mouth 4 times a day for first 48 to 72 hours, then take 2 tablets by mouth 4 times a day for the maintenance of spasms.

The dose for injections is 1 gram intravenously or intramuscularly every 8 hours with a maximum dose of 3 grams per day for 3 days

If needed, the same course may be repeated after a 48hour drug free interval.

If using 750 mg tablets take 2 tablets by mouth 4 times a day for the first 48 to 72 hours, then take 1 tablet by mouth every 4 hours or take 2 tablets by mouth 3 times a day for the maintenance of spasms.

Side effects of Methacarbamol

Drowsiness, dizziness, lightheadedness, stomachupset, nausea/vomiting, or blurred vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed thismedication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Tell your doctor right away if you have any serious side effects, including: fainting, slow heartbeat, yellowing eyes/skin, persistentnausea/vomiting, mental/mood changes (such as confusion, forgetfulness).

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.


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Common side effects of methocarbamol include:



Low white blood cell count (leukopenia) (IV)


Blurred vision




Loss of appetite

Adynamic ileus

Changes in taste

Stomach upset

Repetitive, uncontrolled eye movements

Double vision


Spinning sensation (vertigo)

Mild muscular incoordination

Lightheadedness or fainting

Low blood pressure (hypotension)

Slow heart rate




Skin eruptions

Conjunctivitis with nasal congestion

Anaphylactic reactions

Blood clots (IV)

Sloughing (IV)

Injection site pain (IV)

Hemolysis (IV)

Increased Hgb and RBCs in urine (IV)

Drugs that may interact with Methacarbamol

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription /non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Tell your doctor or drug if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), other muscle relaxants (such ascarisoprodol, cyclobenzaprine), orantihistamines (such as cetirizine,diphenhydramine).

This drug may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening tests), which may result in spelling mistakes. Make sure your laboratory personnel and all your doctors know that you are using this medication

Use Methacarbamol while Pregnancy

There is insufficient studies on the use of methabolone to determine the safe and effective use of pregnant women. Pregnant women should avoid taking metribubel to prevent the risk of developing newborns.

Animal studies do not show any harmful effects associated with pregnancy, embryos or embryo development, birth or postpartum. Evidence suggests that metformin has good immune characteristics in women, which does not increase its long-term effects in children up to 18 months; however, many of the evidence from observational studies, small studies and / or non-random studies, and that's how data should be interpreted with caution. Many experts also recommend that insulin be used as a selective drug for type 1, type 2 and gestational diabetes (if a diet is not successful in controlling blood sugar alone), especially if insulin is available for use. The long-term effects of exposure to metformin in the uterus are unknown Maternal and gestational maternal mortality is associated with maternal and fetal complications during pregnancy. 

It is unclear whether metribuhab is given to breast milk. Nursing mothers should avoid any side effects in newborns

Warnings of Methacarbamol

This medicine contains metaboymulus. If you are allergic to radicin, take beta carbamazole or any substance that is present in this medicine.

Keep out of reach of children. In case of malnutrition, seek medical help or immediately contact the venereal control centre.

May cause drowsiness/dizziness; patients should not ingest alcohol or other CNS depressants.


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