What is Kisqali: Side Effects, How to use, Dosage

What is Kisqali: Side Effects, How to use, Dosage

What is Kisqali?

Kisqali is brand name of ribociclib. (Brand Names: Kisqali, Generic Name: ribociclib)

KISQALI (ribociclib) is a kinase inhibitor.

The chemical name of ribociclib succinate is: Butanedioic acid—7-cyclopentyl-N, N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl] amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide (1/1).

Ribociclib succinate is a light yellow to yellowish brown crystalline powder. The molecular formula for ribociclib succinate is C23H30N8O•C4H6O4 and the molecular weight is 552.64 g/mol (Free base: 434.55 g/mol).

KISQALI film-coated tablets are supplied for oral use and contain 200 mg of ribociclib free base (equivalent to 254.40 mg ribociclib succinate). The tablets also contain colloidal silicon dioxide, crospovidone, hydroxypropylcellulose, magnesium stearate and microcrystalline cellulose. The film-coating contains iron oxide black, iron oxide red, lecithin (soya), polyvinyl alcohol (partially hydrolysed), talc, titanium dioxide, and xanthan gum as inactive ingredients.

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Kisqali Uses

Kisqali (ribociclib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Kisqali is used to treat hormone-related breast cancer in women. Ribociclib is used only if your cancer tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.

Kisqali is used when the cancer has progressed or has spread to other parts of the body after other treatments.

Kisqali is given in combination with another cancer medicine such as letrozole (Femara) or fulvestrant (Faslodex).

Ribociclib is used to treat breast cancer in women after menopause. It works by slowing or stopping the growth of cancer cells.

How to use Kisqali?

Before using: You should not use Kisqali if you are allergic to ribociclib, or if you also take tamoxifen.

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Kisqali.

To make sure Kisqali is safe for you, tell your doctor if you have:

heart disease or prior heart attack;

slow heartbeats;

heart disease or prior heart attack;

long QT syndrome;

an electrolyte imbalance (such as low levels of calcium, magnesium, phosphorus, or potassium in your blood);

liver disease;

kidney disease; or

signs of infection (fever, chills).

Tell your doctor whether or not you have gone through menopause.

You may need to have a negative pregnancy test before starting this treatment.

Do not use Kisqali if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose.

This medicine may affect fertility (ability to have children) in men. Talk with your doctor if you have concerns about this risk.

Read the Patient Information Leaflet if available from your pharmacist before you start taking ribociclib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning for 21 days, then stopping the medication for 7 days. This is one cycle of treatment. Continue taking the medication this way as directed by your doctor.

Swallow the tablet(s) whole. Do not crush, chew, or break the tablet(s). Also, do not take a tablet that is damaged or broken.

If you vomit after taking a dose, do not take another dose at that time. Take your next dose at the regular time.

The dosage is based on your medical condition, response to treatment, lab tests, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Avoid eating grapefruit or pomegranate, and avoid drinking grapefruit juice or pomegranate juice while taking this medication unless your doctor or pharmacist says you may do so safely. Grapefruit or pomegranate can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Skip the missed dose. Take your next dose at the regular time and stay on your once-daily schedule. Do not use 2 doses in one day.

What is Kisqali

Please if you have any questions about KISQALI (ribociclib), you can ask us by commenting below this text, we'll answer you as soon as possible.

Dosage of Kisqali

600 mg orally once a day for 21 consecutive days followed by 7 days off for a complete cycle of 28 days; continue until disease progression or unacceptable toxicity.

Side effects of Kisqali

Fatigue, diarrhea, headache, back pain, nausea, vomiting, or loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Pain or sores in the mouth and throat may occur. Brush your teeth carefully/gently, avoid using mouthwash that contains alcohol, and rinse your mouth often with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk ofside effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, including: signs of liver disease (such as nausea/vomiting that doesn't stop, stomach/abdominal pain, yellowing eyes/skin, dark urine).

Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, severe dizziness, fainting.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Get emergency medical help if you have signs of an allergic reaction to Kisqali: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Furthermore details:

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or

liver problems - loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

In summary

Common Kisqali side effects may include:

low white blood cells, infections;

cough;

nausea, vomiting;

diarrhea, constipation;

feeling tired;

headache; or

hair loss.

Warnings of Kisqali

Before taking ribociclib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

Ribociclib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ribociclib, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics "water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using ribociclib safely.

Ribociclib can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

Ribociclib is used mainly in women after menopause. If you have not gone through menopause, tell your doctor if you are pregnant or plan to become pregnant. Women who may become pregnant should have a pregnancy test before starting this medication. You should not • become pregnant while using ribociclib. Ribociclib may harm an unborn baby. Ask about reliable forms of birth control while taking this medication and for 3 weeks after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 3 weeks after stopping treatment is not recommended. Consult your doctor before breast-feeding.

What is Kisqali

Please if you have any questions about KISQALI (ribociclib), you can ask us by commenting below this text, we'll answer you as soon as possible.

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