What is Evista: How to use, Dosage, Side Effects

What is Evista: How to use, Dosage, Side Effects

What is evista

Evista (raloxifene) affects the bone formation and fracture cycle in the body and prevents bone tissue loss. Evista is used to treat or prevent osteoporosis in postmenopausal women. It is also used to reduce the risk of invasive breast cancer in postmenopausal women.

Raloxifene is used by women to prevent and treat osteoporosis (post osteoporosis) after menopause. It reduces bones and helps to keep bones strong, and they have less chance of breaking.

Raloxifene may also reduce the chance of developing a specific breast cancer (aggressive breast cancer) after menopause.

Raloxifene is not an estrogen hormone, but acts in some parts of the body like bones like estrogen. In other parts of the body (uterus and chest), raloxifene acts like an estrogen blocker. It does not prevent menopausal symptoms such as hot flashes. Raloxifene belongs to a group of drugs known as selective Gestrogen receptor molecule-SERM.

This medicine should not be used before menopause.

It should not be used to prevent heart disease

Please if you have any questions about Evista, you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use evista?

Read the Medication Guide provided by your pharmacist before you start taking raloxifeneand each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take evista by mouth with or without food as directed by your doctor, usually once daily. Take evista regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Be sure to get enough calcium and vitamin Din your diet. Consult your doctor or pharmacist to see if you need to take calciumand vitamin D supplements.

Since evista can be absorbed through theskin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle evista or breathe the dust from the tablets.

Dosage of Evista

Recommended Dosing

The recommended dosage is one 60 mg EVISTA (raloxifene hydrochloride tablets) tablet daily, which may be administered any time of day without regard to meals [see CLINICAL PHARMACOLOGY].

For the indications in risk of invasive breast cancer the optimum duration of treatment is not known [see Clinical Studies].

Recommendations for Calcium And Vitamin D Supplementation

For either osteoporosis treatment or prevention, supplemental calcium and/or vitamin D should be added to the diet if daily intake is inadequate. Postmenopausal women require an average of 1500 mg/day of elemental calcium. Total daily intake of calcium above 1500 mg has not demonstrated additional bone benefits while daily intake above 2000 mg has been associated with increased risk of adverse effects, including hypercalcemia and kidney stones. The recommended intake of vitamin D is 400-800 IU daily.

Patients at increased risk for vitamin D insufficiency (e.g., over the age of 70 years, nursing home bound, or chronically ill) may need additional vitamin D supplements. Patients with gastrointestinalmalabsorption syndromes may require higher doses of vitamin D supplementation and measurement of 25-hydroxyvitamin D should be considered.

overdose

In an 8-week study of 63 postmenopausal women, a dose of raloxifene hydrochloride (HCl) 600 mg/day was safely tolerated. In clinical trials, no raloxifene overdose has been reported.

In postmarketing spontaneous reports, raloxifene overdose has been reported very rarely (less than 1 out of 10,000 [ < 0.01%] patients treated). The highest overdose has been approximately 1.5 grams. No fatalities associated with raloxifene overdose have been reported. Adverse reactions were reported in approximately half of the adults who took ≥ 180 mg raloxifene HCl and included leg cramps and dizziness.

Two 18-month-old children each ingested raloxifene HCl 180 mg. In these two children, symptoms reported included ataxia, dizziness, vomiting, rash, diarrhea, tremor, and flushing, as well as elevation in alkaline phosphatase.

Evista while Pregnancy

Animal studies have revealed fetal malformations, reproductive system abnormalities, and impaired reproductive function in female offspring. Adverse effects observed in animals included abortion, fetal heart anomalies, hydrocephaly, retardation of fetal development, delayed and disrupted parturition, decreased neonatal survival, altered physical development, sex- and age-specific reductions in growth, changes in pituitary hormone content, developmental abnormalities, decreased lymphoid compartment size, uterine hypoplasia, and reduced fertility. There are no controlled data in human pregnancy.

Please if you have any questions about Evista, you can ask us by commenting below this text, we'll answer you as soon as possible.

Side effects of Evista

Along with its needed effects, raloxifene (the active ingredient contained in Evista) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking raloxifene and get emergency help immediately if any of the following effects occur:

Coughing blood

headache or migraine headache

loss of or change in speech, coordination, or vision

pain or numbness in chest, arm, or leg

shortness of breath (unexplained)

Check with your doctor as soon as possible if any of the following side effects occur while taking raloxifene:

Bloody or cloudy urine

chest pain

difficult, burning, or painful urination

fever

frequent urge to urinate

infection, including body aches or pain, congestion in throat, cough, dryness or soreness of throat, runny nose, and loss of voice

leg cramping

skin rash

swelling of hands, ankles, or feet

vaginal itching

Abdominal pain (severe)

aching body pains

congestion in lungs

decreased vision or other changes in vision

diarrhea

difficulty in breathing

hoarseness

loss of appetite

nausea

trouble in swallowing

weakness

Some side effects of raloxifene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Hot flashes, including sudden sweating and feelings of warmth (especially common during the first 6 months of treatment)

increased white vaginal discharge

joint or muscle pain

mental depression

problems of stomach or intestines, including passing of gas, upset stomach, or vomiting

swollen joints

trouble in sleeping

weight gain (unexplained)

Drugs that may interact

Common medications checked in combination with Evista (raloxifene)

aspirin

Calcium 600 D (calcium / vitamin d)

Fosamax (alendronate)

hydrochlorothiazide

levothyroxine

lisinopril

Nexium (esomeprazole)

omeprazole

Prolia (denosumab)

simvastatin

Synthroid (levothyroxine)

Vitamin D3 (cholecalciferol)

Warnings of Evista

Before taking raloxifene, tell your doctor orpharmacist if you are allergic to it, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using evista, tell your doctor or pharmacist your medical history, especially of: blood clots (including in the legs/lungs/eyes), stroke, mini-stroke (TIA), heart disease (blocked blood vessels in theheart), heart attack, high cholesterol, irregular heartbeat called atrial fibrillation, high blood pressure, smoking, kidney disease, liverdisease, heart failure, cancer, high blood fat(triglyceride) levels caused by estrogentreatment.

Tell your doctor if you just had or will be having surgery or if you will be confined to a bed or chair for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are using raloxifene. You may need to stop evista for a time or take specialprecautions.

evista must not be used during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away.

It is unknown if evista passes into breastmilk. Consult your doctor before breast-feeding.

what is evista

Please if you have any questions about Evista, you can ask us by commenting below this text, we'll answer you as soon as possible.

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