What is Xeloda: Side Effects, How to use, Dosage

What is Xeloda: Side Effects, How to use, Dosage

What is Xeloda?

Capecitabine, sold under the brand name   Xeloda is a type of chemotherapy medication used to treat breast cancer, gastric cancer and colorectal cancer. For breast cancer it is often used together with docetaxel. The medicine contained in XELODA tablets, capecitabine, is converted by the liver and cancer cells to another medicine called 5-fluorouracil (also called 5-FU).

It is 5-FU that acts to kill or stop the growth of cancer cells.

This medication is in an inactive form when you take it. Your liver, and then enzymes in the cancer cells, convert it to its active cancer-fighting form, 5-fluorouracil. (Cancer cells contain high levels of an enzyme that converts Xeloda to its active state.) This two-step activation process means that a higher concentration of the medicine ends up in the cancer tissue, rather than in healthy tissue.

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How to use Xeloda?

Xeloda is usually taken twice per day. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

It is given in a 3-week treatment cycle, and you may only need to take the medicine during the first 2 weeks of each cycle. Your doctor will determine how long to treat you with this drug. Also its better to know that Xeloda is only part of a treatment program that may also include other medications taken on different schedules. Follow your doctor's dosing instructions very carefully.

Xeloda should be taken with food or within 30 minutes after eating a meal.

Take this medication with a full glass (8 ounces) of water.

Call your doctor if you are sick with vomiting or diarrhea, if you are unable to eat because of stomach illness, or if you are sweating more than usual. Prolonged illness can lead to dehydration or kidney failure.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests. Xeloda can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medicine.

What is Xeloda

Please if you have any questions about Xeloda, you can ask us by commenting below this text, we'll answer you as soon as possible.

Side effects of Xeloda

Like other medicines Xeloda has some common and some other serious and maybe life threatening side effects that must be cared by the patients and be informed to the doctor in advance or not they may lead to other serious problems. Here is the list of side effects:

fever above 100.5 degrees;

nausea, loss of appetite, eating much less than usual, vomiting (more than once in 24 hours);

severe diarrhea (more than 4 times per day, or during the night);

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet;

dehydration symptoms - feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;

heart problems - chest pain or pressure, uneven heartbeats, shortness of breath (even with mild exertion), swelling or rapid weight gain;

kidney problems - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

low blood cell counts - fever or other flu symptoms, cough, skin sores, pale skin, easy bruising, unusual bleeding, feeling light-headed, rapid heart rate; or

severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Xeloda side effects may include:

stomach pain or upset, constipation;

tired feeling;

mild skin rash; or

numbness or tingling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Dosage of Xeloda

The recommended dose of XELODA is 1250 mg/m2 administered orally twice daily (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1-week rest period given as 3-week cycles.

Adjuvant treatment in patients with Dukes' C colon cancer is recommended for a total of 6 months [ie, XELODA 1250 mg/m2 orally twice daily for 2 weeks followed by a 1-week rest period, given as 3-week cycles for a total of 8 cycles (24 weeks)].

In combination with docetaxel, the recommended dose of XELODA is 1250 mg/m2 twice daily for 2 weeks followed by a 1-week rest period, combined with docetaxel at 75 mg/m2 as a 1-hour intravenous infusion every 3 weeks. Pre-medication, according to the docetaxel labeling, should be started prior to docetaxel administration for patients receiving the XELODA plus docetaxel combination.

Warnings of Xeloda

Before starting Xeloda treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.

Avoid use of antacids within 2 hours of taking Xeloda.

If you are on warfarin as a blood-thinner, adjustments may need to be made to your dose based on blood work.

Xeloda may be inadvisable if you have had a hypersensitivity (allergic) reaction to fluorouracil.

Do not receive any kind of immunization or vaccination without your doctor's approval while taking Xeloda.

Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Xeloda may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

For both men and women: Do not conceive a child (get pregnant) while taking this drug. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

Do not breast feed while taking Xeloda.

Drugs may interact with Xeloda

Drug interactions may change how your medications work or increase your risk for serious side effects.  Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Xeloda is very similar to fluorouracil. Do not use medications containing fluorouracil while using it.

Altered coagulation parameters and/or bleeding have been reported in patients taking XELODA concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon. These events occurred within several days and up to several months after initiating XELODA therapy and, in a few cases, within 1 month after stopping XELODA. These events occurred in patients with and without liver metastases. In a drug interaction study with single-dose warfarin administration, there was a significant increase in the mean AUC of S-warfarin. The maximum observed INR value increased by 91%. This interaction is probably due to an inhibition of cytochrome P450 2C9 by capecitabine and/or its metabolites.

What is Xeloda

Please if you have any questions about Xeloda, you can ask us by commenting below this text, we'll answer you as soon as possible.

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