What is Verzenio: How to use, Dosage, Side Effects

What is Verzenio: How to use, Dosage, Side Effects

What is Verzenio

GENERIC NAME(S): Abemaciclib

This medication is used to treat certain types of breast cancer. Abemaciclib works by slowing or stopping the growth of cancer cells. It belongs to a class of drugs known as kinase inhibitors. Verzenio works to stop these proteins and cells as they are moving to grow and divide2. It slows down the cell growth and division, which causes cancer cells to become inactive or even die. In preclinical studies, continuous exposure to Verzenio slowed down CDK4 & 6 proteins, which delayed cancer cells from growing and dividing.

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FASLODEX is a prescription medicine used to treat women with:

Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer, who have gone through menopause and have not been previously treated with endocrine therapy

HR-positive advanced breast cancer, who have gone through menopause and whose disease has progressed after endocrine therapy

HR-positive, HER2‐negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic), in combination with palbociclib or abemaciclib, in women whose disease has progressed after endocrine therapy

How to use Verzenio

Read the Patient Information Leaflet if available from your pharmacist before you start using abemaciclib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually two times daily. Swallow the tablet whole with a glass of water. Do not chew, crush, or split the tablets. Do not take tablets that are broken, cracked, or not whole.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

TELL YOUR DOCTOR:

If you have an allergy to Verzenio (abemaciclib) or any part of Verzenio (abemaciclib).

If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

If you are taking any of these drugs: Ketoconazole or rifampin.

If you are breast-feeding. Do not breast-feed while you take Verzenio (abemaciclib) and for 3 weeks after your last dose.

This is not a list of all drugs or health problems that interact with Verzenio (abemaciclib

Dosage of Verzenio

When used in combination with fulvestrant or an aromatase inhibitor, the recommended dose of VERZENIO is 150 mg taken orally twice daily.

When given with VERZENIO, refer to the Full Prescribing Information for the recommended dose of the aromatase inhibitor being used.

When given with VERZENIO, the recommended dose of fulvestrant is 500 mg administered on Days 1, 15, and 29; and once monthly thereafter. Refer to the Full Prescribing Information for fulvestrant. Pre/perimenopausal women treated with the combination of VERZENIO plus fulvestrant should be treated with a gonadotropin-releasing hormone agonist according to current clinical practice standards.

When used as monotherapy, the recommended dose of VERZENIO is 200 mg taken orally twice daily.

If the patient vomits or misses a dose of VERZENIO, instruct the patient to take the next dose at its scheduled time. Instruct patients to swallow VERZENIO tablets whole and not to chew, crush, or split tablets before swallowing. Instruct patients not to ingest VERZENIO tablets if broken, cracked, or otherwise not intact.

FASLODEX is administered by your health care provider as an injection into the muscle of each buttock. Your health care provider may change your dose of FASLODEX if needed.

What is Verzenio

Please if you have any questions about Verzenio, you can ask us by commenting below this text, we'll answer you as soon as possible.

Side effects of Verzenio

Loose stools (diarrhea).

Feeling tired or weak.

Upset stomach or throwing up.

Not hungry.

Belly pain.

Headache.

Hard stools (constipation).

Dry mouth.

Mouth irritation or mouth sores.

Joint pain.

Change in taste.

Dizziness.

Hair thinning.

Hair loss.

Weight loss.

if you have any of the following signs or symptoms that may be related to a very bad side effect:

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal

Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.

Very loose stools (diarrhea).

Loose stools (diarrhea) that will not go away.

Feeling very tired or weak.

Any unexplained bruising or bleeding.

Swelling in the arms or legs.

Fast breathing.

A fast heartbeat

STORAGE:

Store at room temperature.

Store in a dry place. Do not store in a bathroom.

Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Verzenio while pregnancy

It’s important to know that women who are pregnant or planning to get pregnant should not take Verzenio. Verzenio can harm the developing fetus. It’s important that you don’t get pregnant while taking Verzenio; if there is any chance you can become pregnant, you must use effective birth control while you’re taking Verzenio and for at least 3 weeks after your last dose.

Also, women who are breastfeeding or plan to breastfeed shouldn’t take Verzenio. Together, you and your doctor will decide if you should take Verzenio or breastfeed.

Warnings of Verzenio

Abemaciclib can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not receive any kind of immunization or vaccination without your doctor's approval while taking Abemaciclib.

Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.

You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.

Wash your hands often.

Use an electric razor and a soft toothbrush to minimize bleeding.

It is common to have diarrhea when taking Verzenio (abemaciclib). Sometimes, diarrhea has been very bad and may cause dehydrationor an infection. Most of the time, diarrhea happened during the first month of treatment. If you get diarrhea, follow what your doctor told you to do. If you are not sure what to do if you get diarrhea, talk with your doctor.

Have blood work checked as you have been told by the doctor. Talk with the doctor.

Patients who experience diarrhea should alert their healthcare provider, initiate antidiarrheal therapy, and increase oral fluids.

What is Verzenio

Please if you have any questions about Verzenio, you can ask us by commenting below this text, we'll answer you as soon as possible.

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