What is Sertraline: Side Effects, Dosage, How to use

What is Sertraline: Side Effects, Dosage, How to use

What is Sertraline

Sertraline is an antidepressant in a group of medications called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms.

Sertraline is used to cure depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder(social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

Sertraline may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may reduce fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. Sertraline is known as a selective serotonin reuptake inhibitor (SSRI). It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.

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How to use sertraline?

Before you start using sertraline and every time you refill, get the pharmacy guide and, if necessary, get patient information provided by your pharmacist. Ask your doctor or pharmacist if you have questions.

Use sertraline as directed by your doctor, usually once a day or in the morning or at night. The pill form of this medicine may be taken with or without food. The shape of the capsule usually feeds after breakfast or after a meal.

If you are taking sertraline for premenstrual problems, your doctor may prescribe you this medicine every day of the month or just 2 weeks before the course until your course starts.

To reduce the risk of side effects, your doctor may want to start using sertraline at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use this medication regularly to get the most out of it. To help you remember, put it at a time every day.

It is important that you continue to take this medication even if you feel well. Do not stop taking medication without consulting your doctor. Some of these conditions may get worse if the drug suddenly stops. You may also experience symptoms such as mood swings, headaches, fatigue, changes in sleep and short feelings like electric arteries. To reduce side effects, it should be gradually reduced. Report new or worse signs every time.

Dosage of Sertraline

The recommended dose of sertraline is 25 to 200 mg once a day. Treatment for depression, OCD, panic disorder, PTSD and social anxiety disorder occurs at 25 to 50 mg once a day. The dose increases at weekly intervals to see the response.

The recommended dose for PMDD is 50 to 150 mg per day from the menstrual cycle or 14 days before menstruation.

Sertraline may be taken with or without food.

Side effects of Sertraline

Sertraline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sertraline:

More Common

  • Decreased sexual desire or ability
  • failure to discharge semen (in men)
  • Aggressive reaction
  • breast tenderness or enlargement
  • confusion
  • convulsions
  • diarrhea
  • drowsiness
  • dryness of the mouth
  • fast talking and excited feelings or actions that are out of control
  • fever
  • inability to sit still
  • increase in body movements
  • increased sweating
  • increased thirst
  • lack of energy
  • loss of bladder control
  • mood or behavior changes
  • muscle spasm or jerking of all extremities
  • nosebleeds
  • overactive reflexes
  • racing heartbeat
  • red or purple spots on the skin
  • restlessness
  • shivering
  • skin rash, hives, or itching
  • sudden loss of consciousness
  • unusual or sudden body or facial movements or postures
  • unusual secretion of milk (in females)
  • Abdominal or stomach pain
  • bleeding gums
  • blindness
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine
  • bloody, black, or tarry stools
  • blue-yellow color blindness
  • blurred vision
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • cough or hoarseness
  • darkened urine
  • decreased urine output
  • decreased vision
  • depressed mood
  • difficulty with breathing
  • difficulty with speaking
  • difficulty with swallowing


Sertraline while Pregnancy

Using sertraline during pregnancy can trigger early-onset symptoms in babies who use sertraline mothers. Infants exposed to SSRIs and SNRIs are suddenly reported at the end of the third trimester. Clinical findings include respiratory distress, cyanosis, apnea, and seizure, temperature instability, feeding problems, vomiting, hypoglycaemia, hypertension, hyper alpha, tremor, itching, irritability and permanent crying. These effects occur more often at birth or during the day. These features are compatible with a direct toxic effect of SSRI and SNRI, or possibly a drug-stopping syndrome. In some cases, the clinical picture is compatible with serotonin syndrome. The results of a cohort study indicate that 30% of infants exposed to long-term exposure to SSRIs in the symptoms of uterine experience respond to new-born's reflux syndrome after delivery. The authors suggest that infants exposed to SSRI should be screened at least 48 hours after birth.

Drugs that may interact with Sertraline

All SSRIs, containing Zoloft, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example

  • isocarboxazid (Marplan),
  • phenelzine (Nardil),
  • tranylcypromine (Parnate),
  • selegiline (Eldepryl, Emsam, Elazar), and
  • procarbazine (Matulane).

Other drugs that inhibit monoamine oxidase include

  • linezolid (Zyvox) and
  • Intravenous methylene blue.

Such a combination may lead to confusion, high blood pressure, tremor, hyperactivity, coma and death. (If you switch between Zoloft and MAOIs, a 14-day treatment period should be discontinued.) Zoloft with other medications such as Tryptophan, Santorum Jonathan, Meperidine (Demerol, Meperitab), Tramadol (ConZip, Synapryn) FusePaq, Ultram) which increases serotonin in the brain.

The cimetidine (Tagamet HB Reducer) may increase the level of Zoloft's blood loss by reducing the amount of zolt by the liver. Increasing Zoloft levels may result in further side effects. (Read full information about Zoloft: What is Zoloft?)

Warnings of Sertraline

Elderly adults may be more susceptible to side effects, especially bleeding or loss of coordination. Elderly adults may most likely cause a type of salt imbalance (hyponatremia), especially if they are taking water tablets (diuretics). Losing coordination can increase the risk of falling.

Children may be more sensitive to side effects, especially loss of appetite and weight loss. Monitor weight and height in children taking this medication.

During pregnancy, this medication should only be needed when needed. It may be harmed to a baby. Also, babies born to mothers who have taken the drug for the last 3 months of pregnancy can rarely develop symptoms such as nourishment / respiration, seizure, muscle stiffness or permanent crying. If you notice any of these symptoms in your baby, tell your doctor immediately.

Since the untreated psychological / psychological problems (such as depression, panic attacks, obsessive-compulsive disorder, and posttraumatic stress disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant or think you may be pregnant, talk to your doctor immediately about the benefits and risks of using this medication during pregnancy.


Please if you have any questions about Sertraline, you can ask us by commenting below this text, we'll answer you as soon as possible.

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