What is Lexapro: Side Effects, Dosage, How to use

What is Lexapro: Side Effects, Dosage, How to use

What is Lexapro

Lexapro is used to treat anxiety in adults.

Lexapro (escitalopram) is an antidepressant in a group of drugs that use selective serotonin reuptake inhibitors (SSRIs).

Lexapro is also used to treat major depressive disorder in adults and adolescents at least 12 years of age. It affects the chemicals in the brain that may be incompatible with those who have depression or anxiety.

Lexapro® (citalopram oxalate) is an orally administered selective serotonin reuptake inhibitor (SSRI). Escitalopram oxalate is designated S-(+)-1-[3(dimethyl-amino) propyl]-1-(p-fluorophen)-5-phthalancarbonitrile oxalate

Escitalopram is the pure Senantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram. (Read full information about escitalopram: What is escitalopram?)

The molecular formula is C20H21FN2O • C2H2O4 and the molecular weight is 414.40.

Scaloporam oxalate is a good powder, white powder to slightly yellow, freely soluble in methanol and dimethyl sulfoxide (DMSO), soluble in phosphate salt solution, soluble in water and ethanol, slightly soluble in ethyl acetate and soluble in Heptane.

Lexapro (Oxalate escitalopram) is available as a tablet or as an oral solution.

The Lexapro oral solution contains escitalopram oxalate equivalent to 1 mg / ml of escitalopram. It also contains inactive ingredients: sorbitol, pure water, citric acid, sodium citrate, malic acid, glycerin, propylene glycol, methyl paraben, propyl paraben and natural mint flavor.

Lexapro tablets, red-coated tablets contain escitalopram oxalate, in different amounts of 5, 10, and 20 mg of sklithopamine. 10 and 20 mg tablets are obtained. The tablet also contains inactive material such as talc, sodium cross Carmel, silicon dioxide, cellulose / colloidal microcrystalline, and magnesium stearate. The film coating includes hypromellose, titanium dioxide and polyethylene glycol.

Please if you have any questions about Lexapro, you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Lexapro?

You may take Lexapro with or without food. Try to take the medicine at the same time every day. Take the liquid medicine with a syringe dose, or with a special spoon for a dose or medicine cup. If you do not have a dose measuring device, ask your pharmacist for one.

Take this medicine with or without food according to your doctor's instructions, usually once in the morning or at night. The dose is based on your medical condition, response to treatment, age, and other medications that you may be taking.

If you use this form of liquid, carefully measure the dose using a special measuring device / spoon. Do not use a spoon because you may not have a proper dose.

Make sure you tell your doctor and pharmacist about all the products you use (including prescription drugs, over-the-counter prescriptions, and herbal products).

Dosage of Lexapro

Lexapro's adult daily intake for general anxiety disorder:

Initial dose: 10 mg once daily. If necessary, increase the dose to 20 mg once a day after at least 1 week.

Maintenance dose: 10 to 20 mg once daily

Maximum dose: 20 mg once daily

Comment: Treatment should be re-evaluated periodically to determine the need for continuous treatment. Efficacy over 8 weeks has not been systematically studied.

Use: Acute treatment of general anxiety disorder

Generally Lexapro daily intake for depression:

Initial dose: 10 mg once daily. If necessary, increase the dose to 20 mg once a day after at least 1 week.

Maintenance dose: 10 to 20 mg once daily

Maximum dose: 20 mg once daily

Comments:

Certain episodes may require several months or more of stable pharmacologic therapy, beyond the response to the acute part.

- Patients should be re-evaluated periodically to determine the need for preservative treatment.

Use: Acute treatment and maintenance of major depressive disorder

Usually Geriatric effects of Lexapro for depression:

Recommended dose: 10 mg once daily

Use: Acute treatment and maintenance of major depressive disorder

Daily intake of children for depression:

12 years and older:

Initial dose: 10 mg once daily. If necessary, increase the dose to 20 mg once a day after at least 3 weeks.

Maintenance dose: 10 to 20 mg once daily

Maximum dose: 20 mg once daily

Comments:

Certain episodes may require several months or more of stable pharmacologic therapy, beyond the response to the acute part.

- Patients should be re-evaluated periodically to determine the need for preservative treatment.

Use: Acute treatment and maintenance of major depressive disorder

Benefits may not be seen until treatment is given for up to 4 weeks. A daily dose of 20 mg may be used to treat depression more than 10 mg per day.

The initial dose of Lexapro to treat depression in adults and adolescents is 10 mg once a day in the morning or at night. The dose may be increased to 1 mg once a day after 3 weeks.

Symptoms of over dose

In clinical studies of Lexapro, excessive use of Lexapro, including over 600 mg, is reported to be associated with no mortality. During the evaluation of the post-sale of Lexapro, Lexapro has been reported to overuse over 1,000 mg. As with other SSRIs, it has rarely been reported as a lethal outcome in patients who have been taking excessive amounts of sklithopamine.

Signs often associated with excessive use of Lexapro, alone or in combination with other drugs or alcohol, including seizure, dizziness, blood pressure, insomnia, nausea, vomiting, sinus tachycardia, drowsiness and ECG changes. QT prolongation and very rare cases of torsade de pointes). Acute over-the-kidney failure with excessive consumption has been reported.

Side effects of Lexapro

Report any new symptoms or worsening to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, drowsiness, or if you feel irritable, irritable, disturbed, hostile, aggressive, restless, Have too much (mentally or physically) depression, or have your thoughts about suicide or harm yourself.

In the case that you have the below effects<get medical help a.s.a.p:

Dark vision, tunnel vision, eye pain or swelling, or viewing aura around the lights;

Racing thoughts, unusual risk appetite, feelings of joy or intense grief;

Low levels of sodium in the body - headache, confusion, impatience, severe weakness, vomiting, loss of coordination, instability; or

Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, rapid or uneven heartbeat, tremor, feeling like you may be erased.

In the cases of symptoms of serotonin syndrome, tell your doctor if you have symptoms of serotonin syndrome, including: irritation, hallucinations, fever, sweating, chills, fast heart rate, muscle stiffness, shaking, coordination, nausea, vomiting or diarrhea. See.

The usual Lexapro side effects may include:

Dizziness, drowsiness, weakness;

Sweating, feeling tight or anxious;

Sleep problems (insomnia);

Dry mouth, loss of appetite;

Nausea, constipation;

Yawn

Weight changes; or

Decreased libido, impotence, or having an orgasm problem.

This list is not the full list of side effects and others may occur.

Nausea, dry mouth, constipation, trouble sleeping, tiredness, drowsiness, dizziness, and increased sweating may occur. If any of these effects persist or worsen, tell your doctor quickly.

Lexapro

Drugs that may interact with Lexapro

Using Lexapro with other drugs that would cause drowsiness can make the effect worse. Ask your doctor before taking a sleeping pill, opiate drugs, sedation, or medication for anxiety, depression or seizure.

Tell your doctor about all the medications you use and those who start or start using Lexapro during treatment.

Any other type of antidepressant

Medication to treat anxiety, mood disorders or mental illness;

Lithium, Santour Jonathan, Tramadol or Tryptophan (sometimes called L-Tryptophan);

Migraine headaches - Sumatriptan, Ratripteran and others;

Blood Drinks - Warfarin, Coumadine, Yanoton;

Antidepressants - fentanyl or tramadol; or

Stimulants or drugs ADHD - Adderall, Concerta, Ritalin and others;

This is not a complete list.

Triptans

There have been rare post marketing reports of serotonin syndrome with use of an SSRI and a triptan. If concomitant treatment of Lexapro with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.

Alcohol

Although Lexapro did not potentiate the cognitive and motor effects of alcohol in a clinical trial, as with other psychotropic medications, the use of alcohol by patients taking Lexapro is not suggested.

CNS Drugs

Given the primary CNS effects of escitalopram, caution should be used when it is taken in combination with other centrally acting drugs.

Drugs That interact with Hemostasis (NSAIDs, Aspirin, Warfarin, Etc.)

Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate the risk of bleeding. Patients receiving warfarin therapy should be carefully monitored when Lexapro is initiated or discontinued. Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are co administered with warfarin.

Cimetidine

The clinical significance of these findings is unknown. In subjects who had received 21 days of 40 mg/day racemic citalopram, combined administration of 400 mg twice a day cimetidine for 8 days resulted in an increase in citalopram AUC and Cmax of 43% and 39%, respectively.

Digoxin

In subjects who had received 21 days of 40 mg/day racemic citalopram, combined administration of citalopram and digoxin (single dose of 1 mg) did not significantly affect the pharmacokinetics of either citalopram or digoxin.

Lithium

Co administration of racemic citalopram (40 mg/day for 10 days) and lithium (30 mmol/day for 5 days) had no significant effect on the pharmacokinetics of citalopram or lithium. Nevertheless, plasma lithium levels should be monitored with appropriate adjustment to the lithium dose in accordance with standard clinical practice. Because lithium may increase the serotonergic effects of escitalopram, caution should be exercised when Lexapro and lithium are co administered.

Pimozide and Celexa

The mechanism of this pharmacodynamics interaction is not known. In a controlled study, a single dose of pimozide 2 mg co-administered with racemic citalopram 40 mg given once daily for 11 days was associated with a mean increase in QTc values of approximately 10 msec compared to pimozide given alone. Racemic citalopram did not alter the mean AUC or Cmax of pimozide.

Sumatriptan

There have been rare post marketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of an SSRI and sumatriptan. If concomitant treatment with sumatriptan and an SSRI (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, escitalopram) is clinically warranted, appropriate observation of the patient is advised.

Theophylline

Combined administration of racemic citalopram (40 mg/day for 21 days) and the CYP1A2 substrate theophylline (single dose of 300 mg) did not affect the pharmacokinetics of theophylline. The effect of theophylline on the pharmacokinetics of citalopram was not evaluated.

Warfarin

Prothrombin time was increased by 5%, the clinical significance of which is unknown. Administration of 40 mg/day racemic citalopram for 21 days did not affect the pharmacokinetics of warfarin, a CYP3A4 substrate.

Carbamazepine

Combined administration of racemic citalopram (40 mg/day for 14 days) and carbamazepine (titrated to 400 mg/day for 35 days) did not significantly affect the pharmacokinetics of carbamazepine, a CYP3A4 substrate. Although trough citalopram plasma levels were unaffected, given the enzyme-inducing properties of carbamazepine, the possibility that carbamazepine might increase the clearance of escitalopram must be considered if the two drugs are co administered.

Triazolam

Combined administration of racemic citalopram (titrated to 40 mg/day for 28 days) and the CYP3A4 substrate triazolam (single dose of 0.25 mg) did not significantly affect the pharmacokinetics of either citalopram or triazolam.

Ketoconazole

Mixtured administration of racemic citalopram (40 mg) and ketoconazole (200 mg), a potent CYP3A4 inhibitor, decreased the Cmax and AUC of ketoconazole by 21% and 10%, respectively, and did not significantly affect the pharmacokinetics of citalopram.

Ritonavir

Combined administration of a single dose of ritonavir (600 mg), both a CYP3A4 substrate and a potent inhibitor of CYP3A4, and escitalopram (20 mg) did not affect the pharmacokinetics of either ritonavir or escitalopram.

CYP3A4 and -2C19 Inhibitors

In vitro studies indicated that CYP3A4 and -2C19 are the primary enzymes involved in the metabolism of escitalopram. However, co administration of escitalopram (20 mg) and ritonavir (600 mg), a potent inhibitor of CYP3A4, did not significantly affect the pharmacokinetics of escitalopram. Because escitalopram is metabolized by multiple enzyme systems, inhibition of a single enzyme may not appreciably decrease escitalopram clearance.

Drugs Metabolized By Cytochrome P4502D6

In vitro studies did not reveal an inhibitory effect of escitalopram on CYP2D6. In addition, steady state levels of racemic citalopram were not significantly different in poor metabolizers and extensive CYP2D6 metabolizers after multiple-dose administration of citalopram, suggesting that co administration, with escitalopram, of a drug that inhibits CYP2D6, is unlikely to have clinically significant effects on escitalopram metabolism. However, there are limited in vivo data suggesting a modest CYP2D6 inhibitory effect for escitalopram, i.e., co administration of escitalopram (20 mg/day for 21 days) with the tricyclic antidepressant desipramine (single dose of 50 mg), a substrate for CYP2D6, resulted in a 40% increase in Cmax and a 100% increase in AUC of desipramine. The clinical significance of this finding is unknown. Nevertheless, caution is indicated in the co administration of escitalopram and drugs metabolized by CYP2D6.

Electroconvulsive Therapy (ECT)

There are no clinical studies of the combined use of ECT and escitalopram.

Metoprolol

Administration of 20 mg/day Lexapro for 21 days in healthy volunteers resulted in a 50% increase in Cmax and 82% increase in AUC of the beta-adrenergic blocker metoprolol (given in a single dose of 100 mg). Increased metoprolol plasma levels have been associated with decreased cardioselectivity. Coad ministration of Lexapro and metoprolol had no clinically significant effects on blood pressure or heart rate.

Drug Abuse and Dependence

Abuse and Dependence

Physical and Psychological Dependence Animal studies recommend that the abuse liability of racemic citalopram is low. Lexapro has not been systematically studied in humans for its potential for abuse, tolerance, or physical dependence. The premarketing clinical experience with Lexapro did not reveal any drug-seeking behavior. However, these observations were not systematic and it is not possible to predict on the basis of this limited experience the extent to which a CNS-active drug will be misused, diverted, and/or abused once marketed. Consequently, physicians should carefully evaluate Lexapro patients for history of drug abuse and follow such patients closely, observing them for signs of misuse or abuse (e.g., development of tolerance, incrementations of dose, drug-seeking behavior).

For whom Lexapro might not be safe

To ensure Lexapro is safe for you, tell your doctor if you have ever had:

Liver or kidney disease;

Seizure

Heart disease, high blood pressure;

Low levels of sodium in your blood;

A bleeding or blood clotting disorder;

Stroke;

Bipolar disorder (Manic depression); or

Drug Addiction or Suicidal Thoughts.

Elderly adults may be more susceptible to side effects, such as QT prolongation (see above), loss of coordination or bleeding. They may be more likely to lose too much salt (Hyponatremia), especially if they also consume water tablets (diuretics) with this medication. Losing coordination can increase the risk of falling.

Children may be more susceptible to side effects, especially loss of appetite and weight loss. Monitor weight and height in children taking this drug.

Lexapro while pregnancy

Using anti-depressant drugs during pregnancy may cause serious lung problems or other complications in the baby. However, if you are taking antidepressants, you may experience a recurrence of depression. If you use Lexapro, tell your doctor immediately about pregnancy.

Do not start or use your medication during pregnancy without consulting your doctor.

During pregnancy, this medication should only be used when needed. It may be harmed to a baby. Also, babies born to mothers who have taken the drug for the last 3 months of pregnancy can rarely develop symptoms such as nourishment / respiration, seizure, muscle stiffness or permanent crying. If you notice any of these symptoms in your baby, tell your doctor immediately.

Warnings of Lexapro

You should not use Lexapro, while you also take Orap or Citalopram (Celexa).

Some young people will commit suicide when they develop antidepressants. Add your mood or sign to your changes. Report any new symptoms or worsening to your doctor.

Do not use Lexapro 14 days or 14 days after using an MAO inhibitor such as isoccarbazole, linzolide, insulin methylated infusion, phenolsin, razogali, selegiline or tranylcypromine.

In the case that symptoms of serotonin syndrome exist, tell your doctor about them, including: irritation, hallucinations, fever, fast heart rate, sweating, chills, muscle stiffness, shaking, coordination, nausea, vomiting or diarrhea. See.

Do not give Lexapro to anyone under the age of 12.

Lexapro

Please if you have any questions about Lexapro, you can ask us by commenting below this text, we'll answer you as soon as possible.

Add comment

Your message is required.