What is Ibrance: How to use, Side Effects, dosage

What is Ibrance: How to use, Side Effects, dosage

What is Ibrance?

Ibrance (palbociclib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Ibrance is used in men and women to treat certain types of advanced breast cancer that has spread to other parts of the body.

In postmenopausal women, Ibrance is given in combination with a hormonal medicine called letrozole (Femara). In others, it is given together with fulvestrant (Faslodex).

Please if you have any questions about Ibrance (palbociclib), you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Ibrance?

Take Ibrance exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Ibrance is given in a 28-day treatment cycle, and you may only need to take the medicine during the first 3 weeks of each cycle. Your doctor will determine how long to treat you with Ibrance.

Take with food.

Take the medicine at the same time each day.

Do not crush, chew, break, or open a Ibrance capsule. Swallow it whole.

If you vomit after taking the medicine, wait until the next day to take your next dose.

Do not use a broken or damaged pill.

Ibrance can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.

When taking Ibrance with Faslodex, it's also taken on a 28-day cycle: you take Ibrance for 21 days at the same time each day, with food, then you stop taking the Ibrance pills for 7 days.

Ibrance dosage

Usual Adult Dose for Breast Cancer:

28-day cycle: 125 mg orally once a day for 21 consecutive days followed by 7 days off treatment

Comments: Take with food in combination with letrozole 2.5 mg orally once a day throughout the 28-day cycle.

Use: In combination with letrozole for the treatment of postmenopausal women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy.

What is Ibrance

Please if you have any questions about Ibrance (palbociclib), you can ask us by commenting below this text, we'll answer you as soon as possible.

Side effect of Ibrance

Get emergency medical help if you have signs of an allergic reaction to Ibrance: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

low white blood cell counts - fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;

low red blood cells (anemia) - pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Ibrance side effects may include:

nausea, vomiting, diarrhea, loss of appetite;

mouth sores, decreased sense of taste;

weakness, feeling tired;

numbness, tingling, or burning pain in your arms, legs, hands or feet;

abnormal liver function tests;

cold symptoms such as stuffy nose, sneezing, sore throat;

nosebleed; or

dry skin, temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ibrance drug interactions:

There may be an interaction between palbociclib and any of the following:

alpha blockers (e.g., alfuzosin, doxazosin, silodosin, tamsulosin)

amiodarone

anti-cancer medications (e.g., cabazitaxel, docetaxel; doxorubicin; etoposide, ifosfamide, irinotecan, vincristine)

anti-psychotics (e.g., aripiprazole, clozapine, haloperidol, olanzapine, quetiapine, risperidone)

"azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)

benzodiazepines (e.g., chlordiazepoxide, clonazepam, diazepam, lorazepam)

boceprevir

bosentan

buspirone

calcitriol

calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)

chloroquine

colchicine

conivaptan

corticosteroids (e.g., budesonide, dexamethasone)

cyclosporine

darifenacin

deferasirox

disopyramide

domperidone

dronedarone

echinacea

estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)

fingolimod

"gliptin" diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)

grapefruit juice

HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)

HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

leflunomide

lidocaine

losartan

macrolide antibiotics (e.g., clarithromycin, erythromycin)

maraviroc

mefloquine

mifepristone

mirtazapine

modafinil

narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)

nefazodone

nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)

phenobarbital

pimecrolimus

praziquantel

primaquine

quinidine

quinine

rifabutin

rifampin

rilpivirine

roflumilast

romidepsin

St. John's wort

seizure medications (e.g., carbamazepine, gabapentin, levetiracetam, phenytoin, topiramate)

selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)

sildenafil

simeprevir

solifenacin

"statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)

tacrolimus

tamoxifen

tocilizumab

tofacitinib

tolterodine

tolvaptan

trazodone

tricyclic antidepressasnts (e.g., amitriptyline, clomipramine, desipramine, trimipramine)

vaccines

venlafaxine

zolpidem

zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist.Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

Missed dose Ibrance

If you miss a dose, skip the missed dose and resume your usual dosing schedule the next day. Do not double the dose to catch up.

Warnings of Ibrance

Before taking palbociclib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

Palbociclib can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Ibrance while pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are using palbociclib. Palbociclib may harm an unborn baby. Women of childbearing age should have a pregnancy test before starting this medication. Women of childbearing age should also ask about reliable forms of birth control while using this medication and for at least 3 weeks after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding during treatment and for at least 3 weeks after treatment with this drug is not recommended. Consult your doctor before breast-feeding.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.

Store at room temperature away from moisture and heat.

What is Ibrance

Please if you have any questions about Ibrance (palbociclib), you can ask us by commenting below this text, we'll answer you as soon as possible.

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