What is Austedo: How To use, Dosage, Side Effects, Warnings

What is Austedo: How To use, Dosage, Side Effects, Warnings

What is Austedo


Austedo is used to treat unwanted muscle movements (chorea) caused by Huntington's disease. Deutetrabenazine is not a treatment for Huntington's disease and does not cure other symptoms. AUSTEDO (deutetrabenazine) is a vesicular monoamine transporter 2 (VMAT2) inhibitor for oral administration. The molecular weight of deutetrabenazine is 323.46; the pKa is 6.31.
Austedo (deutetrabenazine) reduces the amount of certain chemicals in the body that are overactive in people with Huntington's disease. Austedo is also used to treat unpleasant dyskinesia symptoms, nervous system disorders. Permanent dyskinesias cause uncontrollable movements of repetitive muscles, usually in the face (chewing, napping, fluttering, moving the tongue, blinking or moving the eyes). Deutetrabenazine is a hexahydro-dimethoxybenzoquinolizine derivative and has the following chemical name: (RR, SS)-1, 3, 4, 6, 7, 11b-hexahydro-9, 10-di(methoxy-d3)-3-(2-methylpropyl)2H-benzo[a]quinolizin-2-one.
This drug is not a permanent therapy for impaired motor mobility.
The molecular formula for deutetrabenazine is C19H21D6NO3.

 


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How to use Austedo


If you are replacing a similar drug called tetrabenazine (Xenazine), take your first dose of diatraconazine one day after the last dose of tetrabenazine.
Austedo is usually taken 1 to 2 times a day with a meal and a glass of water.
Do not split or chew. If you have trouble swallowing your whole pill, inform your doctor.

 


Dosage of Austedo 


The dose of AUSTEDO is determined individually for each patient based on reduction of chorea or tardive dyskinesia and tolerability. When first prescribed to patients who are not being switched from tetrabenazine (a related VMAT2 inhibitor), the recommended starting dose of AUSTEDO is 6 mg administered orally once daily for patients with Huntington’s disease and 12 mg per day (6 mg twice daily) for patients with tardive dyskinesia.
The dose of AUSTEDO may be increased at weekly intervals in increments of 6 mg per day to a maximum recommended daily dosage of 48 mg.
Administer total daily dosages of 12 mg or above in two divided doses.
The AUSTEDO dose is individually determined for each patient, which is susceptible to tolerance due to the reduction of curia or discontinuation. When first used for tetrabenazine (a VMAT2 inhibitor), the recommended dose of AUSTEDO 6 mg once daily for patients with Huntington's disease and 12 mg / day (6 mg two Times a day) for patients with anxiety dyskinesia.
For patients at risk for QT prolongation, assess the QT interval before and after increasing total AUSTEDO dosage above 24 mg per day [see Warnings and Precautions (5.3) and Drug Interactions (7.2)].
Switching Patients from Tetrabenazine (XENAZINE®) to AUSTEDO
Discontinue tetrabenazine (XENAZINE®) and initiate AUSTEDO the following day.

 


Symptoms of over dose  


Excessive consumption of 100 to 1 gram is closely related to tetrabenizone, a VMAT2 inhibitor. The following unwanted reactions occur during overdose: acute dysplasia, epigastric episode, sedation, nausea and vomiting, sweating, hypertension, confusion, diarrhea, hallucinations, and tremor.
Treatment should include those general measures that are used to manage excessive drug intake with any active drug in the central nervous system. Supportive measures and public symbols are recommended. The heart rhythm and vital signs should be monitored. In the management of over dosage, the possibility of multi-drug interference should always be considered. The doctor should be in the treatment of a venous control center with any kind of abuse.

 

 

 

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Side effects of Austedo


Report any new symptoms or worsening to your doctor, including: spells of cry, changes in weight and appetite, feelings of inferiority, loss of interest in things you once enjoyed, new sleep problems, or If you feel frustrated, guilty, very tired, irritable, hostile, aggressive, or thinking about suicide or masturbation.
Some side effects may in fact be signs that your Huntington disease progresses. Your doctor should check your progress during regular periods.
In the case that you have following side effects, call your doctor:
Fast or sharp heartbeat, chest tightness, shortness of breath and sudden dizziness (as if it might be erased);
Severe boredom or irritation
Shake; tremble;
Muscle stiffness;
Problems with balance or coordination; or
Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, rapid or uneven heartbeat, tremor, feeling like you may be erased.
The usual side effects of Austedo may include:
Drowsiness
feeling exhausted;
Dry mouth;
Runny or stuffy nose, sore throat
Sleep problems (insomnia); or
Diarrhea
This list is not full of side effects and others may occur.
Drugs that may interact with Austedo
Austedo can cause serious heart problems. The risk for this condition may be higher, as well as if you use some other medications for infection, asthma, heart problems, depression, high blood pressure, mental illness, cancer, malaria or HIV.
Using detattranazin with other medicines that cause drowsiness can make the effect worse. Ask your doctor before using sleep pills, opioids, sedation, or medication for anxiety or seizure.
Many medications can interact with Diettrabenazine. This includes prescription and over-the-counter prescriptions, vitamins and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medications and any medication you are taking or not taking.

 


For whom this drug might not be safe


You should not use Austedo if you are allergic to Databases or if you have:
Untreated or uncontrolled depression;
Thoughts about suicide or hurt yourself;
Liver disease; or
If you have recently taken tetrabenazine (xenazine) or valerian (ingrezza).
Do not use Austedo if you have used Spaspin (Serpalan, Renese-R) for the past 20 days, or if you have been taking MAO for 14 days. Dangerous drug interactions may occur. MAO inhibitors include: Isocarboccide, Linzolide, Selegiline, Methylene blue infusion, Phenzelin, Razgali, tranylcypromine and others.
To ensure that Austedo is safe for you, tell your doctor if you have any of these:
Mental illness or psychosis;
Depression, anxiety, anxiety, or irritation
Thoughts or suicide actions;
Breast Cancer;
Heart rhythm disorder;
Long QT syndrome (in you or a family member); or
Electrolyte imbalances (such as low levels of potassium or magnesium in your blood).
People with Huntington disease may have a higher risk of depression and suicidal thoughts and behaviors. Austedo may increase this risk. However, the benefits of using this drug (improving daily life) may be more than any risk of suicide.
The doctor should check your progress on regular visits. Your family or other carers should also consider changes in mood or signs.

 

 

Austedo


Warnings of Austedo


The risk of having a QT duration may increase if you have special medical conditions or other medications that may prolong QT. Before using Diettrabenazine, tell your doctor or pharmacist about all the medicines that you take and if you have one of the following: Heart problems (heart failure, slow heart rate, QT duration in the EKG), history Family specific heart problems (QT lifespan in EKG, sudden cardiac death).
Dosage Benazin may cause a disease that affects the heart rhythm (prolonged QT). 
Lower levels of potassium or magnesium in the blood may also increase your risk of developing QT. This risk may be increased by using certain medications (such as diuretics / water tablets) or if you have severe conditions such as diarrhea or vomiting. Talk with your doctor about taking diatraconazine. The duration of QT can rarely lead to serious / rash, and other symptoms (such as severe dizziness, choking), which can rarely lead to medical attention soon.
 


 

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