Kytril: How to use, Side Effects, Dosage

Kytril: How to use, Side Effects, Dosage

What is Kytril?

KYTRIL Tablets and KYTRIL Oral Solution contain granisetron hydrochloride, an antinauseant and antiemetic agent.

Chemical name: Endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride

Molecular weight: 348.9

Empirical formula: C18H24N4O•HCl

Color: white to off-white

Soluble in: Water and normal saline at 20ºC

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How to use Kytril?

Take Kytril exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Kytril is usually taken only on the day of treatment with chemotherapy or radiation. Your doctor may want you to take only one dose, up to 1 hour before chemotherapy or radiation. For patients undergoing chemotherapy, a second dose of granisetron is sometimes given 12 hours after the first dose. Follow your doctor's dosing instructions very carefully. Do not share this medicine with another person.

Kytril is not likely to be useful if you keep taking it during times when you are not receiving chemotherapy or radiation treatment. Store at room temperature away from moisture, heat, and light.

Dosage of Kytril

The recommended adult dosage of oral KYTRIL (granisetron hydrochloride) is 2 mg once daily or 1 mg twice daily. In the 2 mg once-daily regimen, two 1 mg tablets or 10 mL of KYTRIL (granisetron) Oral Solution (2 teaspoonfuls, equivalent to 2 mg of granisetron) are given up to 1 hour before chemotherapy. In the 1 mg twice-daily regimen, the first 1 mg tablet or one teaspoonful (5 mL) of KYTRIL (granisetron) Oral Solution is given up to 1 hour before chemotherapy, and the second tablet or second teaspoonful (5 mL) of KYTRIL (granisetron) Oral Solution, 12 hours after the first. Either regimen is administered only on the day(s) chemotherapy is given. Continued treatment, while not on chemotherapy, has not been found to be useful.

Overdosage

If you take too much Kytril, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. If Kytril is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Side effects of Kytril

Kytril can cause serious side effects.

Common side effects include:

headache

constipation

lack of energy

diarrhea

stomach (abdomen) pain

indigestion

headache

constipation

lack of energy

drowsiness

diarrhea

KYTRIL Granisetron

Please if you have any questions about Kytril, you can ask us by commenting below this text, we'll answer you as soon as possible.

Common side effects when used for surgery include:

pain

constipation

condition of low blood cell count (anemia)

headache

fever

abdominal pain

increase in liver tests

difficulty falling or staying asleep

slow heart rate

dizziness

increase in white blood cells

anxiety

low blood pressure

diarrhea

gassy

infection

indigestion

high blood pressure

bladder infection

low urine output

coughing

This is not a complete list of Kytril side effects. Ask your doctor or pharmacist for more information.

Do not take Kytril if you:

are allergic to granisetron or any ingredients of the medication

are taking the medication apomorphine

Drugs that may interact with Kytril

Granisetron does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system in vitro. There have been no definitive drug-drug interaction studies to examine pharmacokinetic or pharmacodynamics interaction with other drugs; however, in humans, KYTRIL Injection has been safely administered with drugs representing benzodiazepines, neuroleptics, and anti-ulcer medications commonly prescribed with antiemetic treatments. KYTRIL Injection also does not appear to interact with emetogenic cancer chemotherapies. Because granisetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of granisetron. No specific interaction studies have been conducted in anesthetized patients. In addition, the activity of the cytochrome P-450 subfamily 3A4 (involved in the metabolism of some of the main narcotic analgesic agents) is not modified by KYTRIL in vitro.

In in vitro human microsomal studies, ketoconazole inhibited ring oxidation of KYTRIL. However, the clinical significance of in vivo pharmacokinetic interactions with ketoconazole is not known. In a human pharmacokinetic study, hepatic enzyme induction with phenobarbital resulted in a 25% increase in total plasma clearance of intravenous KYTRIL. The clinical significance of this change is not known.

Warnings of Kytril

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness

There have been occasional reports of drowsiness by people who have taken granisetron. Avoid operating motor vehicles or doing other potentially hazardous activities until you determine the how this medication effects you.

Heart rhythm

Granisetron, like other medications in the same family, can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death. If you are at risk for heart rhythm problems (e.g., people with heart failure, angina, low potassium or magnesium levels), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function

Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Serotonin Syndrome

Severe reactions are possible when granisetron is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression.

If you are taking antidepressants, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of a reaction, such as muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation, get immediate medical attention. Coma and death are possible.

Pregnancy

The safety of granisetron for use by pregnant women has not been established. This medication is not recommended for use during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding

It is not known if granisetron passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children 

The safety and effectiveness of granisetron have not been established for children or adolescents under 18 years of age. Its use by this age group is not recommended.

KYTRIL Granisetron

Please if you have any questions about Kytril, you can ask us by commenting below this text, we'll answer you as soon as possible.

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