What Is Cialis: Side Effects, Doses, How To Take Cialis

What Is Cialis: Side Effects, Doses, How To Take Cialis

What Is Cilias

Cialis or tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Cialis is a medicine that is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. (Read full information about Tadalafil 20mg then Buy Tadalafil 20mg with best price: Tadalafil 20mg)

Keywords: Cialis, erectile dysfunction, impotence, benign prostatic hypertrophy, sexual stimulation, Tadalafil.

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Cialis is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether tadalafil passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding. Sudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others). Most of these people already had certain eye problems or risk fa cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether the medicine was the actual cause of vision loss. Cialis is not approved for use by anyone younger than 18 years old.

How Does Cialis Work

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. 

Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply.

The mechanism for reducing BPH symptoms has not been established. Studies in vitro have demonstrated that tadalafil is a selective inhibitor of PDE5. PDE5 is found in the smooth muscle of the corpus cavernosum, prostate, and bladder as well as in vascular and visceral smooth muscle, skeletal muscle, platelets, kidney, lung, cerebellum, and pancreas. In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. These studies have shown that tadalafil is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7 enzymes, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. 

Tadalafil is >10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. Additionally, tadalafil is 700-fold more potent for PDE5 than for PDE6, which is found in the retina and is responsible for phototransduction. Tadalafil is >9,000-fold more potent for PDE5 than for PDE8, PDE9, and PDE10. Tadalafil is 14-fold more potent for PDE5 than for PDE11A1 and 40-fold more potent for PDE5 than for PDE11A4, two of the four known forms of PDE11. PDE11 is an enzyme found in human prostate, testes, skeletal muscle and in other tissues (e.g., adrenal cortex).

 In vitro, tadalafil inhibits human recombinant PDE11A1 and, to a lesser degree, PDE11A4 activities at concentrations within the therapeutic range. The physiological role and clinical consequence of PDE11 inhibition in humans have not been defined.

Effects Of Cialis On Blood Pressure

Tadalafil 20 mg administered to healthy male subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (difference in the mean maximal decrease of 1.6/0.8 mm Hg, respectively) and in standing Reference ID: 3024692 systolic and diastolic blood pressure (difference in the mean maximal decrease of 0.2/4.6 mm Hg, respectively). In addition, there was no significant effect on heart rate. 

Cialis

Effects Of Cialis

 In clinical pharmacology studies, tadalafil (5 to 20 mg) was shown to potentiate the hypotensive effect of nitrates. Therefore, the use of CIALIS in patients taking any form of nitrates is contraindicated .

 A study was conducted to assess the degree of interaction between nitroglycerin and tadalafil, should nitroglycerin be required in an emergency situation after tadalafil was taken. This was a double-blind, placebo-controlled, crossover study in 150 male subjects at least 40 years of age (including subjects with diabetes mellitus and/or controlled hypertension) and receiving daily doses of tadalafil 20 mg or matching placebo for 7 days.

 Subjects were administered a single dose of 0.4 mg sublingual nitroglycerin (NTG) at prespecified time points, following their last dose of tadalafil (2, 4, 8, 24, 48, 72, and 96 hours after tadalafil). 

The objective of the study was to determine when, after tadalafil dosing, no apparent blood pressure interaction was observed. In this study, a significant interaction between tadalafil and NTG was observed at each time point up to and including 24 hours. At 48 hours, by most hemodynamic measures, the interaction between tadalafil and NTG was not observed, although a few more tadalafil subjects compared to placebo experienced greater blood-pressure lowering at this time point. After 48 hours, the interaction was not detectable.

How To Take Cialis?

Cialis is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. 

Cialis can be taken with or without food. Do not break or split a tablet. Swallow it whole. For erectile dysfunction, take Cialis just before sexual activity but not more than once per day. Cialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.

Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension. Store at room temperature away from moisture and heat. 

Cialis Doses

As Cialis is used as needed, you are not likely to be on a dosing schedule.

Overdose Cialis

Seek emergency medical attention or call the Poison Help line.

Cialis and Alcohol  

Drinking alcohol with this medicine can cause side effects.

Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.

Cialis Side Effects

Get emergency medical help if you have signs of an allergic reaction to Cialis: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex. You could be having a life-threatening side effect.

Stop using this medicine and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • an erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis);
  • vision changes or sudden vision loss;
  • ringing in your ears or sudden hearing loss; or
  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Side Effects Of Cialis

  • headache
  • flushing (warmth, redness, or tingly feeling)
  • nausea, upset stomach
  • stuffy nose
  • muscle pain, back pain, pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or write comments to us for help.

Tadalafil Doses

Usual Adult Dose for Erectile Dysfunction:

Use as needed for ED:

  • Initial dose: 10 mg orally once a day, as needed, prior to sexual activity
  • Maintenance dose: 5 to 20 mg orally once a day, as needed, prior to sexual activity based on individual efficacy and tolerability  Comment: Consider that this drug has shown to improve erectile dysfunction up to 36 hours following dosing, when used as needed.  Once a day use for ED:
  • Initial dose: 2.5 mg orally once a day at approximately the same time, without regard to timing of sexual activity
  • Maintenance dose: 2.5 to 5 mg orally once a day based on individual efficacy and tolerability.  Once daily use for ED and Benign Prostatic Hyperplasia (BPH):  -5 mg orally once a day at approximately the same time, without regard to timing of sexual activity

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Usual Adult Dose for Benign Prostatic Hyperplasia:

Once daily use for BPH: 

 5 mg orally once a day at approximately the same time  

Concomitant administration with finasteride:  

5 mg orally once a day at approximately the same time, for up to 26 weeks  

Comments: The incremental benefit of this drug decreases from 4 weeks until 26 weeks. The incremental benefit of this drug beyond 26 weeks is unknown.  Once daily use for ED and BPH:  

5 mg orally once a day at approximately the same time, without regard to timing of sexual activity  Use: Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).

Drugs will affect Cialis

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • medicines to treat erectile dysfunction or pulmonary arterial hypertension
  • an antibiotic or antifungal medicine
  • antiviral medicine to treat hepatitis C or HIV/AIDS
  • drugs to treat high blood pressure or a prostate disorder
  • seizure medicine.

This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Cialis

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cialis only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Please if you have any question about erectile dysfunction remedies and Cilais  or if you need any recommendation you can contact us in comments and take our free commendations.

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